Technology Process of trimethyl(1-m-tolyl-3-(2-(p-tolylethynyl)phenyl)propa-1,2-dienyl)silane
There total 5 articles about trimethyl(1-m-tolyl-3-(2-(p-tolylethynyl)phenyl)propa-1,2-dienyl)silane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
m-tolylmagnesium bromide;
With
zinc(II) chloride;
In
tetrahydrofuran; diethyl ether;
at 20 ℃;
Inert atmosphere;
With
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; diethyl ether;
at -60 ℃;
for 0.25h;
Inert atmosphere;
1-(2-(4-tolylethynyl)phenyl)-3-(trimethylsilyl)prop-2-ynyl acetate;
In
tetrahydrofuran; diethyl ether;
for 14h;
Inert atmosphere;
DOI:10.1021/jo302524a
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 16 h / 20 °C / Inert atmosphere
2.1: ethylmagnesium bromide / tetrahydrofuran / 0.25 h / 0 - 20 °C / Inert atmosphere
2.2: 0.25 h / 20 °C / Inert atmosphere
3.1: triethylamine; dmap / dichloromethane / 0.5 h / 20 °C / Inert atmosphere
4.1: zinc(II) chloride / tetrahydrofuran; diethyl ether / 20 °C / Inert atmosphere
4.2: 0.25 h / -60 °C / Inert atmosphere
4.3: 14 h / Inert atmosphere
With
dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; ethylmagnesium bromide; triethylamine; zinc(II) chloride;
In
tetrahydrofuran; diethyl ether; dichloromethane;
1.1: |Sonogashira Cross-Coupling / 2.2: |Grignard Reaction;
DOI:10.1021/jo302524a
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 16 h / 20 °C / Inert atmosphere
2.1: ethylmagnesium bromide / tetrahydrofuran / 0.25 h / 0 - 20 °C / Inert atmosphere
2.2: 0.25 h / 20 °C / Inert atmosphere
3.1: triethylamine; dmap / dichloromethane / 0.5 h / 20 °C / Inert atmosphere
4.1: zinc(II) chloride / tetrahydrofuran; diethyl ether / 20 °C / Inert atmosphere
4.2: 0.25 h / -60 °C / Inert atmosphere
4.3: 14 h / Inert atmosphere
With
dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; ethylmagnesium bromide; triethylamine; zinc(II) chloride;
In
tetrahydrofuran; diethyl ether; dichloromethane;
1.1: |Sonogashira Cross-Coupling / 2.2: |Grignard Reaction;
DOI:10.1021/jo302524a
