(R)-3-{[2-(4-cyanophenyl)-1-oxo-2,8-diazaspiro[4.5]decane-8-carbonyl]amino}butyric acid ethyl ester

Base Information

Chemical Name:(R)-3-{[2-(4-cyanophenyl)-1-oxo-2,8-diazaspiro[4.5]decane-8-carbonyl]amino}butyric acid ethyl ester
CAS No.:685544-49-4
Molecular Formula:C₂₂H₂₈N₄O₄
Molecular Weight:412.489
Hs Code.:

Synonyms:(R)-3-{[2-(4-cyanophenyl)-1-oxo-2,8-diazaspiro[4.5]decane-8-carbonyl]amino}butyric acid ethyl ester

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Chemical Property of (R)-3-{[2-(4-cyanophenyl)-1-oxo-2,8-diazaspiro[4.5]decane-8-carbonyl]amino}butyric acid ethyl ester

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Technology Process of (R)-3-{[2-(4-cyanophenyl)-1-oxo-2,8-diazaspiro[4.5]decane-8-carbonyl]amino}butyric acid ethyl ester

There total 11 articles about (R)-3-{[2-(4-cyanophenyl)-1-oxo-2,8-diazaspiro[4.5]decane-8-carbonyl]amino}butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 685544-48-3
3-(4-nitrophenoxycarbonylamino)butyric acid ethyl ester

: 685544-34-7
4-(1-oxo-2,8-diazaspiro[4.5]dec-2-yl)benzonitrile

: 685544-49-4
(R)-3-{[2-(4-cyanophenyl)-1-oxo-2,8-diazaspiro[4.5]decane-8-carbonyl]amino}butyric acid ethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/jm030354b

Reference yield:

: 126400-92-8
(R)-3-Benzyloxycarbonylamino-butyric acid ethyl ester

: 685544-49-4
(R)-3-{[2-(4-cyanophenyl)-1-oxo-2,8-diazaspiro[4.5]decane-8-carbonyl]amino}butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd(OH)2/C / ethyl acetate / 2585.74 Torr

2: 87 percent / DIEA / CH₂Cl₂ / 9 h / 20 °C

3: 85 percent / DIEA / CH₂Cl₂ / 20 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; In dichloromethane; ethyl acetate;
DOI:10.1021/jm030354b

Reference yield:

: 34702-66-4
8-benzyl-2-oxa-8-aza-spiro[4.5]decane-1,3-dione

: 685544-49-4
(R)-3-{[2-(4-cyanophenyl)-1-oxo-2,8-diazaspiro[4.5]decane-8-carbonyl]amino}butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: Et₃N / dimethylformamide / 20 °C

2.1: 3.40 g / acetic anhydride; NaOAc / 2 h / Heating

3.1: NaBH₄ / methanol / 0 - 20 °C

3.2: NaBH₄; TFA / 0 - 20 °C

3.3: 792 mg / acetonitrile; CH₂Cl₂ / 20 °C

4.1: 74 percent / aq. NH₄OAc; Cd-Pb couple / tetrahydrofuran / 20 °C

5.1: 85 percent / DIEA / CH₂Cl₂ / 20 °C

With sodium tetrahydroborate; 10% Cd/Pd; ammonium acetate; sodium acetate; acetic anhydride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm030354b