2(4-Bromo-phenyl)-acetamidine

Base Information

Chemical Name:2(4-Bromo-phenyl)-acetamidine
CAS No.:59104-21-1
Molecular Formula:C8H9BrN2
Molecular Weight:213.077
Hs Code.:2903999090
UNII:64573M8MCH
Wikidata:Q27263703
Mol file:59104-21-1.mol

Synonyms:2(4-BROMO-PHENYL)-ACETAMIDINE;59104-21-1;2-(4-bromophenyl)acetimidamide;Benzeneethanimidamide, 4-bromo-;64573M8MCH;UNII-64573M8MCH;2-(4-bromophenyl)ethanimidamide;2-(4-Bromophenyl)-acetamidine;4-bromophenylacetamidine;4-bromophenyl-acetamidine;SCHEMBL8842456;AMY4665;UZAORPZGWBQCRV-UHFFFAOYSA-N;AKOS000183551;Q27263703

Suppliers and Price of 2(4-Bromo-phenyl)-acetamidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-(4-Bromophenyl)-acetamidine
1g
$ 165.00

Matrix Scientific
2-(4-Bromophenyl)ethanimidamide hydrochloride 97%
1g
$ 249.00

Crysdot
2-(4-Bromophenyl)acetamidinehydrochloride 95+%
5g
$ 677.00

American Custom Chemicals Corporation
2(4-BROMO-PHENYL)-ACETAMIDINE 95.00%
5G
$ 1334.03

American Custom Chemicals Corporation
2(4-BROMO-PHENYL)-ACETAMIDINE 95.00%
1G
$ 764.03

Total 15 raw suppliers

Chemical Property of 2(4-Bromo-phenyl)-acetamidine

Chemical Property:

Vapor Pressure:0.000685mmHg at 25°C
Melting Point:186-188 °C
Refractive Index:1.611
Boiling Point:308.3 °C at 760 mmHg
PKA:11.69±0.40(Predicted)
Flash Point:140.3 °C
PSA：49.87000
Density:1.53 g/cm³
LogP:2.72760
XLogP3:1.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:211.99491
Heavy Atom Count:11
Complexity:139

Purity/Quality:

99% ^*data from raw suppliers

2-(4-Bromophenyl)-acetamidine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1CC(=N)N)Br
Uses 2-(4-Bromophenyl)-acetamidine is a bromo-substituted analog of 2-Phenylacetamidine (P319130); a useful synthetic intermediate used in the synthesis of non-nucleoside reverse transcriptase inhibitors. 2-Phenylacetamidine is also used to prepare naltrexone-derived pyrido- and pyrimidomorphinans.

Technology Process of 2(4-Bromo-phenyl)-acetamidine

There total 2 articles about 2(4-Bromo-phenyl)-acetamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 16532-79-9
4-Bromophenylacetonitrile

: 59104-21-1
2-(4-bromophenyl)acetimidamide

Guidance literature:: With amino(methyl)aluminum chloride; In toluene; at 80 ℃;
DOI:10.1016/S0040-4039(00)88891-7

Reference yield:

: 59104-21-1
2-(4-bromophenyl)acetimidamide

Guidance literature:: /Z0703710261/, NH3-Saettigung (ueber Nacht stehen lassen);

Reference yield:

: 59104-21-1
2-(4-bromophenyl)acetimidamide

: 3-bromo-N,N-bis[(4-methoxyphenyl)methyl]-2-[2-[(4-methoxyphenyl)methyl]-2H-1,2,3,4-tetrazol-5-yl]-6-(trifluoromethyl)benzene-1-sulfonamide

: 2-(3′-(N,N-bis(4-methoxybenzyl)sulfamoyl)-2′-(2-(4-methoxybenzyl)-2H-tetrazol-5-yl)-4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl)acetamide

Guidance literature:: 2-(4-bromophenyl)acetimidamide; With chloro[(tricyclohexylphosphine)-2-(2'-aminobiphenyl)]palladium(II) second generation; potassium acetate; bis(pinacol)diborane; In 1,4-dioxane; at 100 ℃; Inert atmosphere;

3-bromo-N,N-bis[(4-methoxyphenyl)methyl]-2-[2-[(4-methoxyphenyl)methyl]-2H-1,2,3,4-tetrazol-5-yl]-6-(trifluoromethyl)benzene-1-sulfonamide; With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In 1,4-dioxane; water; at 90 ℃; Inert atmosphere;