(3R,7S,8S)-6-ethoxycarbonyl-3,7,8-triphenyl-1,4,6-triazabicyclo[3.3.0]oct-4-ene

Base Information

Chemical Name:(3R,7S,8S)-6-ethoxycarbonyl-3,7,8-triphenyl-1,4,6-triazabicyclo[3.3.0]oct-4-ene
CAS No.:314050-57-2
Molecular Formula:C₂₆H₂₅N₃O₂
Molecular Weight:411.503
Hs Code.:

Synonyms:(3R,7S,8S)-6-ethoxycarbonyl-3,7,8-triphenyl-1,4,6-triazabicyclo[3.3.0]oct-4-ene

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Chemical Property of (3R,7S,8S)-6-ethoxycarbonyl-3,7,8-triphenyl-1,4,6-triazabicyclo[3.3.0]oct-4-ene

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Technology Process of (3R,7S,8S)-6-ethoxycarbonyl-3,7,8-triphenyl-1,4,6-triazabicyclo[3.3.0]oct-4-ene

There total 8 articles about (3R,7S,8S)-6-ethoxycarbonyl-3,7,8-triphenyl-1,4,6-triazabicyclo[3.3.0]oct-4-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 314050-54-9
2-(2-hydroxy-1-phenyl-ethylimino)-4,5-diphenyl-imidazolidine-1-carboxylic acid ethyl ester

: 314050-57-2
(3R,7S,8S)-6-ethoxycarbonyl-3,7,8-triphenyl-1,4,6-triazabicyclo[3.3.0]oct-4-ene

: (4S,5S)-2-[(E)-(R)-2-Chloro-1-phenyl-ethylimino]-4,5-diphenyl-imidazolidine-1-carboxylic acid ethyl ester

Guidance literature:: With 2-chloro-1,3-dimethylimidazolinium chloride; triethylamine; In dichloromethane; at 20 ℃; for 17h; Title compound not separated from byproducts;
DOI:10.1021/jo000746f

Reference yield: 40.0%

: 314050-54-9
(4S,5S)-4,5-diphenyl-1-ethoxycarbonyl-2-[(R)-2-hydroxy-1-phenylethylimino]imidazolidine

: 314050-57-2
(3R,7S,8S)-6-ethoxycarbonyl-3,7,8-triphenyl-1,4,6-triazabicyclo[3.3.0]oct-4-ene

: (4S,5S)-2-[(E)-(R)-2-Chloro-1-phenyl-ethylimino]-4,5-diphenyl-imidazolidine-1-carboxylic acid ethyl ester

Guidance literature:: With 2-chloro-1,3-dimethylimidazolinium chloride; triethylamine; In dichloromethane; at 20 ℃; for 17h; Title compound not separated from byproducts;
DOI:10.1021/jo000746f

Reference yield:

: 314050-52-7
(4S,5S)-2-[(R)-2-(tert-butyldimethylsilyloxy)-1-phenylethylimino]-4,5-diphenyl-1-ethoxycarbonylimidazolidine

: 314050-57-2
(3R,7S,8S)-6-ethoxycarbonyl-3,7,8-triphenyl-1,4,6-triazabicyclo[3.3.0]oct-4-ene

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / tetrabutylammonium fluoride / tetrahydrofuran / 3 h / 20 °C

2: 40 percent / 2-chloro-1,3-dimethylimidazolinium chloride; Et₃N / CH₂Cl₂ / 17 h / 20 °C

With tetrabutyl ammonium fluoride; 2-chloro-1,3-dimethylimidazolinium chloride; triethylamine; In tetrahydrofuran; dichloromethane; 1: Elimination / 2: Cyclization;
DOI:10.1021/jo000746f