3-bromo-4-methyl-6-phenyl-1-(tert-butyloxycarbonyl)-5,6-dihydro-pyridin-2-one

Base Information

Chemical Name:3-bromo-4-methyl-6-phenyl-1-(tert-butyloxycarbonyl)-5,6-dihydro-pyridin-2-one
CAS No.:727425-41-4
Molecular Formula:C₁₇H₂₀BrNO₃
Molecular Weight:366.255
Hs Code.:

Synonyms:3-bromo-4-methyl-6-phenyl-1-(tert-butyloxycarbonyl)-5,6-dihydro-pyridin-2-one

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Chemical Property of 3-bromo-4-methyl-6-phenyl-1-(tert-butyloxycarbonyl)-5,6-dihydro-pyridin-2-one

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Technology Process of 3-bromo-4-methyl-6-phenyl-1-(tert-butyloxycarbonyl)-5,6-dihydro-pyridin-2-one

There total 4 articles about 3-bromo-4-methyl-6-phenyl-1-(tert-butyloxycarbonyl)-5,6-dihydro-pyridin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 727425-40-3
3-bromo-4-methyl-6-phenyl-5,6-dihydro-pyridin-2-one

: 727425-41-4
3-bromo-4-methyl-6-phenyl-1-(tert-butyloxycarbonyl)-5,6-dihydro-pyridin-2-one

Guidance literature:: With dmap; triethylamine; In dichloromethane; for 12h;
DOI:10.1016/j.tet.2004.04.021

Reference yield:

: 541-47-9
3-Methylbutenoic acid

: 727425-41-4
3-bromo-4-methyl-6-phenyl-1-(tert-butyloxycarbonyl)-5,6-dihydro-pyridin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: bromine / CH₂Cl₂

2: piperidine / tetrahydrofuran / 24 h / 20 °C

3: SOCl₂ / 2 h / Heating

4: 92 percent / triethylamine / CH₂Cl₂ / Heating

5: 70 percent / ceric ammonium nitrate / acetonitrile; H₂O / 3 h / 20 °C

6: 90 percent / 4-(dimethylamino)pyridine; triethylamine / CH₂Cl₂ / 12 h

With piperidine; dmap; thionyl chloride; ammonium cerium(IV) nitrate; bromine; triethylamine; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1016/j.tet.2004.04.021

Reference yield:

: 1578-14-9
2-bromo-3-methyl-crotonic acid

: 727425-41-4
3-bromo-4-methyl-6-phenyl-1-(tert-butyloxycarbonyl)-5,6-dihydro-pyridin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂ / 2 h / Heating

2: 92 percent / triethylamine / CH₂Cl₂ / Heating

3: 70 percent / ceric ammonium nitrate / acetonitrile; H₂O / 3 h / 20 °C

4: 90 percent / 4-(dimethylamino)pyridine; triethylamine / CH₂Cl₂ / 12 h

With dmap; thionyl chloride; ammonium cerium(IV) nitrate; triethylamine; In dichloromethane; water; acetonitrile;
DOI:10.1016/j.tet.2004.04.021