1-methyl-3-((4-methylene-1-tosylpyrrolidin-3-yl)(phenyl)methyl)-1H-indole

Base Information

• Chemical Name: 1-methyl-3-((4-methylene-1-tosylpyrrolidin-3-yl)(phenyl)methyl)-1H-indole
• CAS No.: 1359684-02-8
• Molecular Formula: C₂₈H₂₈N₂O₂S
• Molecular Weight: 456.609
• Mol file: 1359684-02-8.mol

Synonyms:1-methyl-3-((4-methylene-1-tosylpyrrolidin-3-yl)(phenyl)methyl)-1H-indole

Chemical Property of 1-methyl-3-((4-methylene-1-tosylpyrrolidin-3-yl)(phenyl)methyl)-1H-indole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of 1-methyl-3-((4-methylene-1-tosylpyrrolidin-3-yl)(phenyl)methyl)-1H-indole

There total 2 articles about 1-methyl-3-((4-methylene-1-tosylpyrrolidin-3-yl)(phenyl)methyl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methylindole (603-76-9) + N-cinnamyl-4-methyl-N-(prop-2-yn-1-yl)-benzenesulfonamide (373640-90-5) → 1-methyl-3-((4-methylene-1-tosylpyrrolidin-3-yl)(phenyl)methyl)-1H-indole (1359684-02-8) + 1-methyl-3-((4-methylene-1-tosylpyrrolidin-3-yl)(phenyl)methyl)-1H-indole (1359684-00-6)

Guidance literature:

With silver hexafluoroantimonate; C₃₂H₂₇AuIN₃; In 1,2-dichloro-ethane; at 25 ℃; for 24h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1016/j.tetasy.2011.12.004

Reference yield:

1-methylindole (603-76-9) + N-cinnamyl-4-methyl-N-(prop-2-yn-1-yl)-benzenesulfonamide (373640-90-5) → 1-methyl-3-((4-methylene-1-tosylpyrrolidin-3-yl)(phenyl)methyl)-1H-indole (1359684-02-8) + 1-methyl-3-((4-methylene-1-tosylpyrrolidin-3-yl)(phenyl)methyl)-1H-indole (1359684-00-6) + 1-methyl-3-((4-methylene-1-tosylpyrrolidin-3-yl)(phenyl)methyl)-1H-indole

Guidance literature:

With silver hexafluoroantimonate; C₃₀H₂₅AuIN₃; In 1,2-dichloro-ethane; at 25 ℃; for 24h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1016/j.tetasy.2011.12.004

upstream raw materials:

1-methylindole

N-cinnamyl-4-methyl-N-(prop-2-yn-1-yl)-benzenesulfonamide