cyclo(-(S)-Phe-(S)-Pro-(S)-Ile-(S)-aThr-(S)-Phe-(S)-Pro-Thz-)

Base Information

Chemical Name:cyclo(-(S)-Phe-(S)-Pro-(S)-Ile-(S)-aThr-(S)-Phe-(S)-Pro-Thz-)
CAS No.:347191-27-9
Molecular Formula:C₄₁H₅₁N₇O₇S
Molecular Weight:785.965
Hs Code.:

Synonyms:cyclo(-(S)-Phe-(S)-Pro-(S)-Ile-(S)-aThr-(S)-Phe-(S)-Pro-Thz-)

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Chemical Property of cyclo(-(S)-Phe-(S)-Pro-(S)-Ile-(S)-aThr-(S)-Phe-(S)-Pro-Thz-)

Chemical Property:

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Technology Process of cyclo(-(S)-Phe-(S)-Pro-(S)-Ile-(S)-aThr-(S)-Phe-(S)-Pro-Thz-)

There total 42 articles about cyclo(-(S)-Phe-(S)-Pro-(S)-Ile-(S)-aThr-(S)-Phe-(S)-Pro-Thz-) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-((S)-1-{(S)-2-[(2S,3S)-2-((2S,3S)-2-{[(S)-1-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-methyl-pentanoylamino)-3-hydroxy-butyrylamino]-3-phenyl-propionyl}-pyrrolidin-2-yl)-thiazole-4-carboxylic acid

: 347191-27-9
cyclo(-(S)-Phe-(S)-Pro-(S)-Ile-(S)-aThr-(S)-Phe-(S)-Pro-Thz-)

Guidance literature:: Multi-step reaction with 2 steps

1: HCl / dioxane; H₂O / 0.33 h / 20 °C

2: 50 mg / pentafluorophenyl diphenylphosphinate; N,N-diisopropylethylamine / dimethylformamide / 50 h / 20 °C

With hydrogenchloride; pentafluorophenyl diphenyl-phosphinate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(02)00906-7

Reference yield:

: 404909-88-2
2-((S)-1-{(S)-2-[(2S,3S)-2-((2S,3S)-2-{[(S)-1-((S)-2-Amino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-methyl-pentanoylamino)-3-hydroxy-butyrylamino]-3-phenyl-propionyl}-pyrrolidin-2-yl)-thiazole-4-carboxylic acid

: 347191-27-9
cyclo(-(S)-Phe-(S)-Pro-(S)-Ile-(S)-aThr-(S)-Phe-(S)-Pro-Thz-)

Guidance literature:: With pentafluorophenyl diphenyl-phosphinate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 50h;
DOI:10.1055/s-2001-14641

Reference yield:

: 69610-41-9,117625-90-8
Boc-L-Pro-H

: 347191-27-9
cyclo(-(S)-Phe-(S)-Pro-(S)-Ile-(S)-aThr-(S)-Phe-(S)-Pro-Thz-)

Guidance literature:: Multi-step reaction with 13 steps

1: 758 mg / triethylamine / toluene / 0 - 20 °C

2: 51 percent / chemical manganese dioxide / molecular sieves 4 Angstroem / benzene / 2 h / Heating

3: HCl / dioxane; H₂O / 0.33 h / 20 °C

4: 2.492 g / diethyl phosphorocyanidate; triethylamine / dimethylformamide / 8 h / 0 - 20 °C

5: 4N aq. HCl / dioxane / 0.33 h / 20 °C

6: 1.581 g / diethyl phosphorocyanidate; triethylamine / dimethylformamide / 8 h / 0 - 20 °C

7: HCl / methanol; dioxane; H₂O / 0.33 h / 20 °C

8: 1.399 g / diethyl phosphorocyanidate; triethylamine / dimethylformamide / 7 h / 0 - 20 °C

9: HCl / dioxane; H₂O / 0.33 h / 20 °C

10: 508 mg / diethyl phosphorocyanidate; triethylamine / dimethylformamide / 14.5 h / 0 - 20 °C

11: LiOH / H₂O; tetrahydrofuran / 1 h / 0 - 20 °C

12: HCl / dioxane; H₂O / 0.33 h / 20 °C

13: 50 mg / pentafluorophenyl diphenylphosphinate; N,N-diisopropylethylamine / dimethylformamide / 50 h / 20 °C

With hydrogenchloride; manganese(IV) oxide; lithium hydroxide; diethyl cyanophosphonate; pentafluorophenyl diphenyl-phosphinate; triethylamine; N-ethyl-N,N-diisopropylamine; 4 A molecular sieve; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1016/S0040-4020(02)00906-7