1-tert-butyl 3-methyl 4-{[(1R)-1-phenylethyl]amino}-5,6-dihydropyridine-1,3(2H)-dicarboxylate

Base Information

• Chemical Name: 1-tert-butyl 3-methyl 4-{[(1R)-1-phenylethyl]amino}-5,6-dihydropyridine-1,3(2H)-dicarboxylate
• CAS No.: 362489-59-6
• Molecular Formula: C₂₀H₂₈N₂O₄
• Molecular Weight: 360.453

Synonyms:1-tert-butyl 3-methyl 4-{[(1R)-1-phenylethyl]amino}-5,6-dihydropyridine-1,3(2H)-dicarboxylate

Chemical Property of 1-tert-butyl 3-methyl 4-{[(1R)-1-phenylethyl]amino}-5,6-dihydropyridine-1,3(2H)-dicarboxylate

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Technology Process of 1-tert-butyl 3-methyl 4-{[(1R)-1-phenylethyl]amino}-5,6-dihydropyridine-1,3(2H)-dicarboxylate

There total 3 articles about 1-tert-butyl 3-methyl 4-{[(1R)-1-phenylethyl]amino}-5,6-dihydropyridine-1,3(2H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

4-((R)-1-phenyl-ethylamino)-1,2,5,6-tetrahydro-pyridine-3-carboxylic acid methyl ester + di-tert-butyl dicarbonate (24424-99-5) → 1-tert-butyl 3-methyl 4-{[(1R)-1-phenylethyl]amino}-5,6-dihydropyridine-1,3(2H)-dicarboxylate (362489-59-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 25 ℃; for 19h;

Reference yield:

(R)-1-phenyl-ethyl-amine (3886-69-9) + methyl 1-tert-butoxycarbonyl-4-oxo-3-piperidinecarboxylate (161491-24-3) → 1-tert-butyl 3-methyl 4-{[(1R)-1-phenylethyl]amino}-5,6-dihydropyridine-1,3(2H)-dicarboxylate (362489-59-6)

Guidance literature:

With p-toluenesulfonic acid monohydrate; In toluene;

Reference yield:

(R)-1-phenyl-ethyl-amine (3886-69-9) + 1-tert-butyl 3-methyl 4-hydroxy-5,6-dihydropyridine-1,3(2H)-dicarboxylate (220389-30-0) → 1-tert-butyl 3-methyl 4-{[(1R)-1-phenylethyl]amino}-5,6-dihydropyridine-1,3(2H)-dicarboxylate (362489-59-6)

Guidance literature:

With acetic acid; In tetrahydrofuran; methanol; for 3h; Reflux;

DOI:10.1016/j.tetasy.2009.07.046

upstream raw materials:

(R)-1-phenyl-ethyl-amine

methyl 1-tert-butoxycarbonyl-4-oxo-3-piperidinecarboxylate

di-tert-butyl dicarbonate

1-tert-butyl 3-methyl 4-hydroxy-5,6-dihydropyridine-1,3(2H)-dicarboxylate

Downstream raw materials:

4-((R)-1-phenyl-ethylamino)-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester

1-tert-butyl 3-methyl (3S,4R)-4-{[(1R)-1-phenylethyl]-amino}piperidine-1,3-dicarboxylate

1-tert-butyl 3-methyl (3R,4R)-4-{[(1R)-1-phenylethyl]-amino}piperidine-1,3-dicarboxylate

1-tert-butyl 3-methyl (3R,4S)-4-{[(1R)-1-phenylethyl]-amino}piperidine-1,3-dicarboxylate

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