1-CBZ-2-(2-HYDROXY-ETHYL)-PIPERIDINE

Base Information

• Chemical Name: 1-CBZ-2-(2-HYDROXY-ETHYL)-PIPERIDINE
• CAS No.: 39945-50-1
• Molecular Formula: C15H21 N O3
• Molecular Weight: 263.337
• Hs Code.: 2933399090
• Mol file: 39945-50-1.mol

Synonyms:1-Benzyloxycarbonyl-2-piperidineethanol;2-(2-Hydroxyethyl)piperidine-1-carboxylic acid benzyl ester

Chemical Property of 1-CBZ-2-(2-HYDROXY-ETHYL)-PIPERIDINE

Chemical Property:

• Vapor Pressure: 2.06E-07mmHg at 25°C
• Boiling Point: 408.7°C at 760 mmHg
• Flash Point: 201°C
• PSA: 49.77000
• Density: 1.14g/cm³
• LogP: 2.49800

Purity/Quality:

97% ^*data from raw suppliers

1-Cbz-2-(2-hydroxy-ethyl)piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-CBZ-2-(2-HYDROXY-ETHYL)-PIPERIDINE

There total 5 articles about 1-CBZ-2-(2-HYDROXY-ETHYL)-PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2(RS)-(2-hydroxyethyl)piperidine (1484-84-0) + benzyl chloroformate (501-53-1,94274-21-2) → 2-(2-hydroxyethyl)-piperidine-1-carboxylic acid benzyl ester (39945-50-1)

Guidance literature:

With potassium carbonate; In ethanol; water; at 0 - 20 ℃; for 3.25h;

DOI:10.1002/ejoc.200900064

Reference yield: 93.0%

2(RS)-(2-hydroxyethyl)piperidine (1484-84-0) + N-(Benzyloxycarbonyloxy)succinimide (13139-17-8) → 2-(2-hydroxyethyl)-piperidine-1-carboxylic acid benzyl ester (39945-50-1)

Guidance literature:

In 1,4-dioxane; water; at 25 ℃; for 24h;

DOI:10.1039/c2ob25943e

Reference yield:

(5,7-Dihydroxy-heptyl)-carbamic acid benzyl ester → 2-(2-hydroxyethyl)-piperidine-1-carboxylic acid benzyl ester (39945-50-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) SOCl₂, 2) NaIO₄ / 2) RuCl₃

2: 1) NaH, 2) conc. HCl / 1) THF, r.t., 24 h, 2) THF, EtOH

With hydrogenchloride; sodium periodate; thionyl chloride; sodium hydride; ruthenium trichloride;

DOI:10.1055/s-1997-699

upstream raw materials:

2(RS)-(2-hydroxyethyl)piperidine

benzyl chloroformate

N-(Benzyloxycarbonyloxy)succinimide

Downstream raw materials:

N-<(benzyloxy)carbonyl>-2-<2-(tert-butyldimethylsiloxy)ethyl>piperidine

2-(2-Methanesulfonyloxy-ethyl)-piperidine-1-carboxylic Acid Benzyl Ester

N-[(R)-phenylalanyl]-2(RS)-{2-[N-(N,N'-di-t-butoxycarbonylamidino)-4-piperidyloxy]ethyl}piperidine

N-[N-(2,2,2-trichloroethoxycarbonyl)-(R)-cyclohexylalanyl]-2(RS)-[2-(N-t-butoxycarbonyl-4-piperidinyloxy)ethyl]piperidine