(E)-(R)-3-((S)-1-Dibenzylamino-2-methyl-propyl)-5-methyl-hepta-4,6-dienal

Base Information

• Chemical Name: (E)-(R)-3-((S)-1-Dibenzylamino-2-methyl-propyl)-5-methyl-hepta-4,6-dienal
• CAS No.: 258826-39-0
• Molecular Formula: C₂₆H₃₃NO
• Molecular Weight: 375.554
• Mol file: 258826-39-0.mol

Synonyms:(E)-(R)-3-((S)-1-Dibenzylamino-2-methyl-propyl)-5-methyl-hepta-4,6-dienal

Chemical Property of (E)-(R)-3-((S)-1-Dibenzylamino-2-methyl-propyl)-5-methyl-hepta-4,6-dienal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-(R)-3-((S)-1-Dibenzylamino-2-methyl-propyl)-5-methyl-hepta-4,6-dienal

There total 1 articles about (E)-(R)-3-((S)-1-Dibenzylamino-2-methyl-propyl)-5-methyl-hepta-4,6-dienal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

(E)-(S)-4-Dibenzylamino-5-methyl-hex-2-enal (138041-59-5) → (E)-(R)-3-((S)-1-Dibenzylamino-2-methyl-propyl)-5-methyl-hepta-4,6-dienal (258826-39-0)

Guidance literature:

In tetrahydrofuran; diethyl ether; at -78 - 5 ℃;

Reference yield: 90.0%

(E)-(R)-3-((S)-1-Dibenzylamino-2-methyl-propyl)-5-methyl-hepta-4,6-dienal (258826-39-0) → (E)-(R)-3-((S)-1-Dibenzylamino-2-methyl-propyl)-5-methyl-hepta-4,6-dien-1-ol (258826-40-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; Heating;

Reference yield:

(E)-(R)-3-((S)-1-Dibenzylamino-2-methyl-propyl)-5-methyl-hepta-4,6-dienal (258826-39-0) → Benzyl-{(E)-(1S,2R)-1-isopropyl-2-[2-(2-methoxy-ethoxymethoxy)-ethyl]-4-methyl-hexa-3,5-dienyl}-amine

Guidance literature:

Multi-step reaction with 3 steps

1.1: 90 percent / LiAlH₄ / tetrahydrofuran / Heating

2.1: n-BuLi / tetrahydrofuran / 0 °C

2.2: 95 percent / tetrahydrofuran / 0 - 20 °C

3.1: 70 percent / DDQ; H₂O / CH₂Cl₂ / 20 °C

With lithium aluminium tetrahydride; n-butyllithium; water; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane; 1.1: Reduction / 2.1: Metallation / 2.2: Alkylation / 3.1: Oxidation;

upstream raw materials:

(E)-(S)-4-Dibenzylamino-5-methyl-hex-2-enal

Downstream raw materials:

(E)-(R)-3-((S)-1-Dibenzylamino-2-methyl-propyl)-5-methyl-hepta-4,6-dien-1-ol

Dibenzyl-{(E)-(1S,2R)-1-isopropyl-2-[2-(2-methoxy-ethoxymethoxy)-ethyl]-4-methyl-hexa-3,5-dienyl}-amine