1-(2,6-dimethylphenyl)-3-methoxymethyl-5-oxo-pyrrolidine-3-carboxylic acid (3,5-bis-trifluoromethylphenyl)amide

Base Information

Chemical Name:1-(2,6-dimethylphenyl)-3-methoxymethyl-5-oxo-pyrrolidine-3-carboxylic acid (3,5-bis-trifluoromethylphenyl)amide
CAS No.:1280200-34-1
Molecular Formula:C₂₃H₂₂F₆N₂O₃
Molecular Weight:488.43
Hs Code.:

Synonyms:1-(2,6-dimethylphenyl)-3-methoxymethyl-5-oxo-pyrrolidine-3-carboxylic acid (3,5-bis-trifluoromethylphenyl)amide

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Chemical Property of 1-(2,6-dimethylphenyl)-3-methoxymethyl-5-oxo-pyrrolidine-3-carboxylic acid (3,5-bis-trifluoromethylphenyl)amide

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Technology Process of 1-(2,6-dimethylphenyl)-3-methoxymethyl-5-oxo-pyrrolidine-3-carboxylic acid (3,5-bis-trifluoromethylphenyl)amide

There total 6 articles about 1-(2,6-dimethylphenyl)-3-methoxymethyl-5-oxo-pyrrolidine-3-carboxylic acid (3,5-bis-trifluoromethylphenyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1280200-86-3
C₁₅H₁₉NO₄

: 328-74-5
3,5-Bis-(trifluoromethyl)aniline

: 1280200-34-1
1-(2,6-dimethylphenyl)-3-methoxymethyl-5-oxo-pyrrolidine-3-carboxylic acid (3,5-bis-trifluoromethylphenyl)amide

Guidance literature:: C₁₅H₁₉NO₄; With methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 0.0833333h;

3,5-Bis-(trifluoromethyl)aniline; In tetrahydrofuran; at 20 - 75 ℃; for 3h;

Reference yield:

: 97-65-4,25119-64-6
2-methylenesuccinic acid

: 1280200-34-1
1-(2,6-dimethylphenyl)-3-methoxymethyl-5-oxo-pyrrolidine-3-carboxylic acid (3,5-bis-trifluoromethylphenyl)amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 0.75 h / 130 °C

2.1: acetyl chloride / 1 h / 64 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / -50 - 0 °C

3.2: 2 h / 0 - 20 °C

4.1: water; lithium hydroxide / methanol / 2 h / 75 °C

4.2: pH 4

5.1: N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride / tetrahydrofuran / 0.08 h / 20 °C

5.2: 3 h / 20 - 75 °C

With water; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; acetyl chloride; lithium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol;

Reference yield:

: 87-62-7
2,6-dimethylaniline

: 1280200-34-1
1-(2,6-dimethylphenyl)-3-methoxymethyl-5-oxo-pyrrolidine-3-carboxylic acid (3,5-bis-trifluoromethylphenyl)amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 0.75 h / 130 °C

2.1: acetyl chloride / 1 h / 64 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / -50 - 0 °C

3.2: 2 h / 0 - 20 °C

4.1: water; lithium hydroxide / methanol / 2 h / 75 °C

4.2: pH 4

5.1: N-ethyl-N,N-diisopropylamine; methanesulfonyl chloride / tetrahydrofuran / 0.08 h / 20 °C

5.2: 3 h / 20 - 75 °C

With water; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; acetyl chloride; lithium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol;