4-[4-methyl-2-(7-piperidin-1-yl-pyrimido[4,5-d]pyrimidin-4-ylamino)-phenylsulfanyl]-phenol trifluoroacetate

Base Information

Chemical Name:4-[4-methyl-2-(7-piperidin-1-yl-pyrimido[4,5-d]pyrimidin-4-ylamino)-phenylsulfanyl]-phenol trifluoroacetate
CAS No.:1076222-91-7
Molecular Formula:C₂HF₃O₂*C₂₄H₂₄N₆OS
Molecular Weight:558.584
Hs Code.:

Synonyms:4-[4-methyl-2-(7-piperidin-1-yl-pyrimido[4,5-d]pyrimidin-4-ylamino)-phenylsulfanyl]-phenol trifluoroacetate

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Chemical Property of 4-[4-methyl-2-(7-piperidin-1-yl-pyrimido[4,5-d]pyrimidin-4-ylamino)-phenylsulfanyl]-phenol trifluoroacetate

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Technology Process of 4-[4-methyl-2-(7-piperidin-1-yl-pyrimido[4,5-d]pyrimidin-4-ylamino)-phenylsulfanyl]-phenol trifluoroacetate

There total 3 articles about 4-[4-methyl-2-(7-piperidin-1-yl-pyrimido[4,5-d]pyrimidin-4-ylamino)-phenylsulfanyl]-phenol trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 110-89-4
piperidine

: 1076222-90-6
4-[2-(7-ethylsulfanyl-pyrimido[4,5-d]pyrimidin-4-ylamino)-4-methyl-phenylsulfanyl]-phenol trifluoroacetate

: 76-05-1
trifluoroacetic acid

: 1076222-91-7
4-[4-methyl-2-(7-piperidin-1-yl-pyrimido[4,5-d]pyrimidin-4-ylamino)-phenylsulfanyl]-phenol trifluoroacetate

Guidance literature:: piperidine; 4-[2-(7-ethylsulfanyl-pyrimido[4,5-d]pyrimidin-4-ylamino)-4-methyl-phenylsulfanyl]-phenol trifluoroacetate; at 180 ℃; for 2h;

trifluoroacetic acid;

Reference yield:

: 16462-29-6
4-amino-2-(ethylthio)pyrimidine-5-carbonitrile

: 1076222-91-7
4-[4-methyl-2-(7-piperidin-1-yl-pyrimido[4,5-d]pyrimidin-4-ylamino)-phenylsulfanyl]-phenol trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: toluene / 2.5 h / Heating / reflux

2: acetic acid / 1.5 h / 130 °C

3: 2 h / 180 °C

In acetic acid; toluene;