2-(benzamidomethyl)-4-<2'-<4'-(carbomethoxy)-4',5'-dihydrooxazolyl>>thiazole

Base Information

Chemical Name:2-(benzamidomethyl)-4-<2'-<4'-(carbomethoxy)-4',5'-dihydrooxazolyl>>thiazole
CAS No.:174149-06-5
Molecular Formula:C₁₆H₁₅N₃O₄S
Molecular Weight:345.379
Hs Code.:

Synonyms:2-(benzamidomethyl)-4-<2'-<4'-(carbomethoxy)-4',5'-dihydrooxazolyl>>thiazole

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Chemical Property of 2-(benzamidomethyl)-4-<2'-<4'-(carbomethoxy)-4',5'-dihydrooxazolyl>>thiazole

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Technology Process of 2-(benzamidomethyl)-4-<2'-<4'-(carbomethoxy)-4',5'-dihydrooxazolyl>>thiazole

There total 6 articles about 2-(benzamidomethyl)-4-<2'-<4'-(carbomethoxy)-4',5'-dihydrooxazolyl>>thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 174149-05-4
2-(benzamidomethyl)-4-carbamoyl>thiazole

: 174149-06-5
2-(benzamidomethyl)-4-<2'-<4'-(carbomethoxy)-4',5'-dihydrooxazolyl>>thiazole

Guidance literature:: With Burgess Reagent; In tetrahydrofuran; at 90 ℃; for 2h;
DOI:10.1021/jo951023c

Reference yield:

: 5692-27-3
2-benzamido-ethanenitrile

: 174149-06-5
2-(benzamidomethyl)-4-<2'-<4'-(carbomethoxy)-4',5'-dihydrooxazolyl>>thiazole

Guidance literature:: Multi-step reaction with 5 steps

1: 83 percent / H₂S, NH₄OH / ethanol / 4 h

2: 74 percent / 2 h / Heating

3: 75 percent / aq. potassium carbonate / methanol; tetrahydrofuran / 6 h / Ambient temperature

4: 58 percent / 1-hydroxybenzotriazole hydrate, Et₃N, dicyclohexylcarbodiimide / tetrahydrofuran / 1) 0 deg C, 4 h; 2) rt, 10 h

5: 60 percent / methyl N-<(triethylammonio)sulfonyl>carbamate / tetrahydrofuran / 2 h / 90 °C

With ammonium hydroxide; Burgess Reagent; hydrogen sulfide; potassium carbonate; 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; ethanol;
DOI:10.1021/jo951023c

Reference yield:

: 55443-42-0
N-(2-amino-2-thioxoethyl)benzamide

: 174149-06-5
2-(benzamidomethyl)-4-<2'-<4'-(carbomethoxy)-4',5'-dihydrooxazolyl>>thiazole

Guidance literature:: Multi-step reaction with 4 steps

1: 74 percent / 2 h / Heating

2: 75 percent / aq. potassium carbonate / methanol; tetrahydrofuran / 6 h / Ambient temperature

3: 58 percent / 1-hydroxybenzotriazole hydrate, Et₃N, dicyclohexylcarbodiimide / tetrahydrofuran / 1) 0 deg C, 4 h; 2) rt, 10 h

4: 60 percent / methyl N-<(triethylammonio)sulfonyl>carbamate / tetrahydrofuran / 2 h / 90 °C

With Burgess Reagent; potassium carbonate; 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol;
DOI:10.1021/jo951023c