4-N-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(N-methylcarbamoyl)ethyl]cytidine

Base Information

Chemical Name:4-N-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(N-methylcarbamoyl)ethyl]cytidine
CAS No.:949158-44-5
Molecular Formula:C₃₆H₄₀N₄O₉
Molecular Weight:672.735
Hs Code.:

Synonyms:4-N-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(N-methylcarbamoyl)ethyl]cytidine

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Chemical Property of 4-N-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(N-methylcarbamoyl)ethyl]cytidine

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Technology Process of 4-N-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(N-methylcarbamoyl)ethyl]cytidine

There total 5 articles about 4-N-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(N-methylcarbamoyl)ethyl]cytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 949158-43-4
4-N-acetyl-2'-O-[2-(N-methylcarbamoyl)ethyl]cytidine

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 949158-44-5
4-N-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(N-methylcarbamoyl)ethyl]cytidine

Guidance literature:: In pyridine; at 20 ℃; for 5h; Inert atmosphere;
DOI:10.1021/jo101963z

Reference yield:

: 1285534-84-0
2'-O-[2-(methoxycarbonyl)ethyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)cytidine

: 949158-44-5
4-N-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(N-methylcarbamoyl)ethyl]cytidine

Guidance literature:: Multi-step reaction with 4 steps

1: methanol / 6 h / 20 °C / Inert atmosphere

2: pyridine / 4 h / 20 °C / Inert atmosphere

3: triethylamine tris(hydrogen fluoride); triethylamine / tetrahydrofuran / 18 h / 20 °C / Inert atmosphere

4: pyridine / 5 h / 20 °C / Inert atmosphere

With triethylamine tris(hydrogen fluoride); triethylamine; In tetrahydrofuran; pyridine; methanol;
DOI:10.1021/jo101963z

Reference yield:

: 949158-41-2
2'-O-[2-(n-methylcarbamoyl)ethyl]-3'-5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)cytidine

: 949158-44-5
4-N-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(N-methylcarbamoyl)ethyl]cytidine

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 4 h / 20 °C / Inert atmosphere

2: triethylamine tris(hydrogen fluoride); triethylamine / tetrahydrofuran / 18 h / 20 °C / Inert atmosphere

3: pyridine / 5 h / 20 °C / Inert atmosphere

With triethylamine tris(hydrogen fluoride); triethylamine; In tetrahydrofuran; pyridine;
DOI:10.1021/jo101963z