isoxazole-5-carboxylic acid (1-{4-[3-chloro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-indol-1-yl]-benzylcarbamoyl}-cyclopropyl)-amide

Base Information

Chemical Name:isoxazole-5-carboxylic acid (1-{4-[3-chloro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-indol-1-yl]-benzylcarbamoyl}-cyclopropyl)-amide
CAS No.:1374455-32-9
Molecular Formula:C₂₆H₂₁ClN₆O₄
Molecular Weight:516.944
Hs Code.:

Synonyms:isoxazole-5-carboxylic acid (1-{4-[3-chloro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-indol-1-yl]-benzylcarbamoyl}-cyclopropyl)-amide

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Chemical Property of isoxazole-5-carboxylic acid (1-{4-[3-chloro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-indol-1-yl]-benzylcarbamoyl}-cyclopropyl)-amide

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Technology Process of isoxazole-5-carboxylic acid (1-{4-[3-chloro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-indol-1-yl]-benzylcarbamoyl}-cyclopropyl)-amide

There total 10 articles about isoxazole-5-carboxylic acid (1-{4-[3-chloro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-indol-1-yl]-benzylcarbamoyl}-cyclopropyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 21169-71-1
isoxazole-5-carboxylic acid

: 1374452-01-3
1-amino-cyclopropanecarboxylic acid 4-[3-chloro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-indol-1-yl]-benzylamide

: 1374455-32-9
isoxazole-5-carboxylic acid (1-{4-[3-chloro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-indol-1-yl]-benzylcarbamoyl}-cyclopropyl)-amide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield: 91.0%

: 21169-71-1
isoxazole-5-carboxylic acid

: 1-amino-cyclopropanecarboxylic acid 4-[3-chloro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-indol-1-yl]-benzylamide hydrochloride

: 1374455-32-9
isoxazole-5-carboxylic acid (1-{4-[3-chloro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-indol-1-yl]-benzylcarbamoyl}-cyclopropyl)-amide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 20h;

Reference yield:

: 28737-32-8
3-chloro-1H-indole-2-carboxylic acid

: 1374455-32-9
isoxazole-5-carboxylic acid (1-{4-[3-chloro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-indol-1-yl]-benzylcarbamoyl}-cyclopropyl)-amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: N,N-dimethyl-formamide; thionyl chloride / 3 h / Reflux

1.2: 2 h / Cooling with ice

2.1: trichlorophosphate / chloroform / 3 h / Reflux

3.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / methanol / 24 h / 20 °C

4.1: acetic acid / 10 h / 90 °C

5.1: N-ethyl-N,N-diisopropylamine / copper diacetate / dimethyl sulfoxide / 144 h / 20 °C / Molecular sieve

5.2: 2 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dimethyl sulfoxide / 2 h / 20 °C

7.1: hydrogenchloride / ethyl acetate / 12 h / 20 °C

7.2: 0.33 h

8.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / dichloromethane; N,N-dimethyl-formamide / 18 h / 20 °C

With hydrogenchloride; thionyl chloride; hydroxylamine hydrochloride; sodium hydrogencarbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trichlorophosphate; copper diacetate; In methanol; dichloromethane; chloroform; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;