(S)-N-((S)-1-tert-Butoxycarbonyl-2-phenyl-ethyl)-3-[2-(4-thiocarbamoyl-benzoylamino)-acetylamino]-succinamic acid tert-butyl ester

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Chemical Name:(S)-N-((S)-1-tert-Butoxycarbonyl-2-phenyl-ethyl)-3-[2-(4-thiocarbamoyl-benzoylamino)-acetylamino]-succinamic acid tert-butyl ester
CAS No.:1025822-82-5
Molecular Formula:C₃₁H₄₀N₄O₇S
Molecular Weight:612.747
Hs Code.:

Synonyms:(S)-N-((S)-1-tert-Butoxycarbonyl-2-phenyl-ethyl)-3-[2-(4-thiocarbamoyl-benzoylamino)-acetylamino]-succinamic acid tert-butyl ester

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Chemical Property of (S)-N-((S)-1-tert-Butoxycarbonyl-2-phenyl-ethyl)-3-[2-(4-thiocarbamoyl-benzoylamino)-acetylamino]-succinamic acid tert-butyl ester

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Technology Process of (S)-N-((S)-1-tert-Butoxycarbonyl-2-phenyl-ethyl)-3-[2-(4-thiocarbamoyl-benzoylamino)-acetylamino]-succinamic acid tert-butyl ester

There total 4 articles about (S)-N-((S)-1-tert-Butoxycarbonyl-2-phenyl-ethyl)-3-[2-(4-thiocarbamoyl-benzoylamino)-acetylamino]-succinamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-3-(2-Benzyloxycarbonylamino-acetylamino)-N-((S)-1-tert-butoxycarbonyl-2-phenyl-ethyl)-succinamic acid tert-butyl ester

: 1025822-82-5
(S)-N-((S)-1-tert-Butoxycarbonyl-2-phenyl-ethyl)-3-[2-(4-thiocarbamoyl-benzoylamino)-acetylamino]-succinamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C / ethanol

2: O-benzotriazol-1-yl-N,N,N',N'-tetramethyluronium hexafluorophosphate (HBTU), N-methylmorpholine (NMM) / tetrahydrofuran / 6 h / Ambient temperature

3: H₂S, triethylamine (TEA) / pyridine / Ambient temperature

With 4-methyl-morpholine; hydrogen sulfide; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; pyridine; ethanol;
DOI:10.1021/jm00101a017

Reference yield:

: 144411-97-2
N-<3-(tert-butoxycarbonyl)-N--L-alanyl>-3-phenyl-L-alanine tert-butyl ester

: 1025822-82-5
(S)-N-((S)-1-tert-Butoxycarbonyl-2-phenyl-ethyl)-3-[2-(4-thiocarbamoyl-benzoylamino)-acetylamino]-succinamic acid tert-butyl ester

Guidance literature:: With hydrogen sulfide; triethylamine; In pyridine; Ambient temperature;
DOI:10.1021/jm00101a017

Reference yield:

: 619-65-8,333406-09-0
4-cyanobenzoic Acid

: 1025822-82-5
(S)-N-((S)-1-tert-Butoxycarbonyl-2-phenyl-ethyl)-3-[2-(4-thiocarbamoyl-benzoylamino)-acetylamino]-succinamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: O-benzotriazol-1-yl-N,N,N',N'-tetramethyluronium hexafluorophosphate (HBTU), N-methylmorpholine (NMM) / tetrahydrofuran / 6 h / Ambient temperature

2: H₂S, triethylamine (TEA) / pyridine / Ambient temperature

With 4-methyl-morpholine; hydrogen sulfide; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In tetrahydrofuran; pyridine;
DOI:10.1021/jm00101a017