3β-{2-[2-(2-{4-[4-(2-chloroacetamido)benzoyl]benzamido}ethoxy)ethoxy]acetoxy}olean-12-en-28-oic acid

Base Information

Chemical Name:3β-{2-[2-(2-{4-[4-(2-chloroacetamido)benzoyl]benzamido}ethoxy)ethoxy]acetoxy}olean-12-en-28-oic acid
CAS No.:1356007-68-5
Molecular Formula:C₅₂H₆₉ClN₂O₉
Molecular Weight:901.581
Hs Code.:

Synonyms:3β-{2-[2-(2-{4-[4-(2-chloroacetamido)benzoyl]benzamido}ethoxy)ethoxy]acetoxy}olean-12-en-28-oic acid

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Chemical Property of 3β-{2-[2-(2-{4-[4-(2-chloroacetamido)benzoyl]benzamido}ethoxy)ethoxy]acetoxy}olean-12-en-28-oic acid

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Technology Process of 3β-{2-[2-(2-{4-[4-(2-chloroacetamido)benzoyl]benzamido}ethoxy)ethoxy]acetoxy}olean-12-en-28-oic acid

There total 13 articles about 3β-{2-[2-(2-{4-[4-(2-chloroacetamido)benzoyl]benzamido}ethoxy)ethoxy]acetoxy}olean-12-en-28-oic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1356007-66-3
3β-[2-(2-{2-[4-(4-aminobenzoyl)benzamido]ethoxy}ethoxy)acetoxy]olean-12-en-28-oic acid

: 627-11-2
2-Chloroethyl chloroformate

: 1356007-68-5
3β-{2-[2-(2-{4-[4-(2-chloroacetamido)benzoyl]benzamido}ethoxy)ethoxy]acetoxy}olean-12-en-28-oic acid

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1016/j.bmcl.2011.11.123

Reference yield:

: 1356007-64-1
3β-[2-(2-{2-[4-(4-nitrobenzoyl)benzamido]ethoxy}ethoxy)acetoxy]olean-12-en-28-oic acid

: 1356007-68-5
3β-{2-[2-(2-{4-[4-(2-chloroacetamido)benzoyl]benzamido}ethoxy)ethoxy]acetoxy}olean-12-en-28-oic acid

Guidance literature:: Multi-step reaction with 2 steps

1: tin(II) chloride dihdyrate / ethanol / 20 h / 70 °C

2: triethylamine / dichloromethane / 3 h / 20 °C

With tin(II) chloride dihdyrate; triethylamine; In ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2011.11.123

Reference yield:

: 1356007-57-2
BnBr

: 1356007-68-5
3β-{2-[2-(2-{4-[4-(2-chloroacetamido)benzoyl]benzamido}ethoxy)ethoxy]acetoxy}olean-12-en-28-oic acid

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 5 h / 20 °C

2: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 20 h / 20 °C

3: pyridine / 2 h / 0 - 20 °C

4: tin(II) chloride dihdyrate / ethanol / 20 h / 70 °C

5: triethylamine / dichloromethane / 3 h / 20 °C

With pyridine; tin(II) chloride dihdyrate; palladium 10% on activated carbon; hydrogen; triethylamine; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2011.11.123