4-chloromethyl-N-(4-methyl-3-[4-(1-oxy-pyridin-3-yl)-[2-⁽¹⁴⁾C]pyrimidin-2-ylamino]-phenyl)-benzamide hydrochloride

Base Information

• Chemical Name: 4-chloromethyl-N-(4-methyl-3-[4-(1-oxy-pyridin-3-yl)-[2-⁽¹⁴⁾C]pyrimidin-2-ylamino]-phenyl)-benzamide hydrochloride
• CAS No.: 917358-62-4
• Molecular Formula: C₂₄H₂₀ClN₅O₂*ClH
• Molecular Weight: 484.358

Synonyms:4-chloromethyl-N-(4-methyl-3-[4-(1-oxy-pyridin-3-yl)-[2-⁽¹⁴⁾C]pyrimidin-2-ylamino]-phenyl)-benzamide hydrochloride

Chemical Property of 4-chloromethyl-N-(4-methyl-3-[4-(1-oxy-pyridin-3-yl)-[2-⁽¹⁴⁾C]pyrimidin-2-ylamino]-phenyl)-benzamide hydrochloride

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Technology Process of 4-chloromethyl-N-(4-methyl-3-[4-(1-oxy-pyridin-3-yl)-[2-⁽¹⁴⁾C]pyrimidin-2-ylamino]-phenyl)-benzamide hydrochloride

There total 1 articles about 4-chloromethyl-N-(4-methyl-3-[4-(1-oxy-pyridin-3-yl)-[2-⁽¹⁴⁾C]pyrimidin-2-ylamino]-phenyl)-benzamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methyl-N3-(4-pyridin-3-yl-[2-(14)C]pyrimidin-2-yl)-benzene-1,3-diamine (917358-54-4) + p-(chloromethyl)benzoyl chloride (876-08-4) → 4-chloromethyl-N-(4-methyl-3-[4-(1-oxy-pyridin-3-yl)-[2-(14)C]pyrimidin-2-ylamino]-phenyl)-benzamide hydrochloride (917358-62-4)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 16h;

Reference yield:

1-methyl-piperazine (109-01-3) + 4-chloromethyl-N-(4-methyl-3-[4-(1-oxy-pyridin-3-yl)-[2-(14)C]pyrimidin-2-ylamino]-phenyl)-benzamide hydrochloride (917358-62-4) → 14C-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide (917358-52-2)

Guidance literature:

1-methyl-piperazine; 4-chloromethyl-N-(4-methyl-3-[4-(1-oxy-pyridin-3-yl)-[2-⁽¹⁴⁾C]pyrimidin-2-ylamino]-phenyl)-benzamide hydrochloride; In ethanol; at 45 ℃; for 5h;

With sodium hydroxide; water; In ethanol; at 20 - 90 ℃; for 0.5h;

upstream raw materials:

4-methyl-N₃-(4-pyridin-3-yl-[2-⁽¹⁴⁾C]pyrimidin-2-yl)-benzene-1,3-diamine

p-(chloromethyl)benzoyl chloride

Downstream raw materials:

¹⁴C-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

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