METHYL 3-PYRIMIDIN-5-YL-ACRYLATE

Base Information

• Chemical Name: METHYL 3-PYRIMIDIN-5-YL-ACRYLATE
• CAS No.: 224776-14-1
• Molecular Formula: C₈H₈N₂O₂
• Molecular Weight: 164.164
• Mol file: 224776-14-1.mol

Synonyms:3-Pyrimidin-5-yl-acrylic acid methyl ester;

Chemical Property of METHYL 3-PYRIMIDIN-5-YL-ACRYLATE

Chemical Property:

• Vapor Pressure: 0.0021mmHg at 25°C
• Refractive Index: 1.567
• Boiling Point: 290.2 °C at 760 mmHg
• Flash Point: 129.3 °C
• PSA: 52.08000
• Density: 1.199 g/cm³
• LogP: 0.66280

Purity/Quality:

99% ^*data from raw suppliers

Methyl3-(pyrimidin-5-yl)acrylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of METHYL 3-PYRIMIDIN-5-YL-ACRYLATE

There total 1 articles about METHYL 3-PYRIMIDIN-5-YL-ACRYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

5-bromopyrimidine (4595-59-9) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → (E)-methyl 3-(5-pyrimidinyl)acrylate (866621-24-1,224776-14-1)

Guidance literature:

With palladium diacetate; N-ethyl-N,N-diisopropylamine; phosphorous acid trimethyl ester; In N,N-dimethyl-formamide; at 110 ℃; for 1h; Inert atmosphere;

DOI:10.1021/op050106k

Reference yield:

(E)-methyl 3-(5-pyrimidinyl)acrylate (866621-24-1,224776-14-1) → methyl 3-(5-pyrimidyl)propionate (224776-16-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 50 ℃;

upstream raw materials:

5-bromopyrimidine

acrylic acid methyl ester

Downstream raw materials:

methyl 3-(5-pyrimidyl)propionate

Refernces

• 1、 You, Hyun,Youn, Hyung-Seop,Im, Isak,Bae, Man-Ho,Lee, Sang-Kook,Ko, Hyojin,Eom, Soo Hyun,Kim, Yong-Chul. "Design, synthesis and X-ray crystallographic study of NAmPRTase inhibitors as anti-cancer agents". experimental part. p. 1153 - 1164. Retrieved 2011/04/17.