tert-butyl 2-bromo-5-(dibenzylamino)phenyl(((chloromethyl)dimethylsilyl)methyl)carbamate

Base Information

Chemical Name:tert-butyl 2-bromo-5-(dibenzylamino)phenyl(((chloromethyl)dimethylsilyl)methyl)carbamate
CAS No.:1622406-50-1
Molecular Formula:C₂₉H₃₆BrClN₂O₂Si
Molecular Weight:588.06
Hs Code.:

Synonyms:tert-butyl 2-bromo-5-(dibenzylamino)phenyl(((chloromethyl)dimethylsilyl)methyl)carbamate

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Chemical Property of tert-butyl 2-bromo-5-(dibenzylamino)phenyl(((chloromethyl)dimethylsilyl)methyl)carbamate

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Technology Process of tert-butyl 2-bromo-5-(dibenzylamino)phenyl(((chloromethyl)dimethylsilyl)methyl)carbamate

There total 5 articles about tert-butyl 2-bromo-5-(dibenzylamino)phenyl(((chloromethyl)dimethylsilyl)methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 2917-46-6
bis(chloromethyl)dimethylsilane

: 1622407-09-3
tert-butyl 2-bromo-5-(dibenzylamino)phenylcarbamate

: 1622406-50-1
tert-butyl 2-bromo-5-(dibenzylamino)phenyl(((chloromethyl)dimethylsilyl)methyl)carbamate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 80 ℃; for 3h;
DOI:10.3987/COM-18-S(T)70

Reference yield:

: C₁₆H₂₃BrN₂O₄

: 1622406-50-1
tert-butyl 2-bromo-5-(dibenzylamino)phenyl(((chloromethyl)dimethylsilyl)methyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium iodide; potassium carbonate / N,N-dimethyl-formamide / 20 h / 20 °C / Inert atmosphere

2.1: potassium carbonate / methanol / 7 h / Reflux; Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h / Inert atmosphere

3.2: 80 °C / Inert atmosphere

With sodium hydride; potassium carbonate; sodium iodide; In methanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/chem.201402597

Reference yield:

: 1622407-08-2
C₃₀H₃₅BrN₂O₄

: 1622406-50-1
tert-butyl 2-bromo-5-(dibenzylamino)phenyl(((chloromethyl)dimethylsilyl)methyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / methanol / 7 h / Reflux; Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h / Inert atmosphere

2.2: 80 °C / Inert atmosphere

With sodium hydride; potassium carbonate; In methanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/chem.201402597