N,N'-bis[1-(5-tert-butyl-2-methoxyphenyl)-2-hydroxyethyl]-2,2-dimethylmalonamide

Base Information

• Chemical Name: N,N'-bis[1-(5-tert-butyl-2-methoxyphenyl)-2-hydroxyethyl]-2,2-dimethylmalonamide
• CAS No.: 796042-60-9
• Molecular Formula: C₃₁H₄₆N₂O₆
• Molecular Weight: 542.716
• Mol file: 796042-60-9.mol

Synonyms:N,N'-bis[1-(5-tert-butyl-2-methoxyphenyl)-2-hydroxyethyl]-2,2-dimethylmalonamide

Chemical Property of N,N'-bis[1-(5-tert-butyl-2-methoxyphenyl)-2-hydroxyethyl]-2,2-dimethylmalonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N'-bis[1-(5-tert-butyl-2-methoxyphenyl)-2-hydroxyethyl]-2,2-dimethylmalonamide

There total 1 articles about N,N'-bis[1-(5-tert-butyl-2-methoxyphenyl)-2-hydroxyethyl]-2,2-dimethylmalonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2,2-Dimethylmalonyl chloride (5659-93-8) + 2-amino-2-(5-tert-butyl-2-methoxy-phenyl)-ethanol; hydrochloride → N,N'-bis[1-(5-tert-butyl-2-methoxyphenyl)-2-hydroxyethyl]-2,2-dimethylmalonamide (796042-60-9)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/ol048179w

Reference yield: 85.0%

N,N'-bis[1-(5-tert-butyl-2-methoxyphenyl)-2-hydroxyethyl]-2,2-dimethylmalonamide (796042-60-9) → (S,S)-2,2'-isopropylidenebis[4-(5-tert-butyl-2-methoxyphenyl)-2-oxazoline] (796042-64-3)

Guidance literature:

N,N'-bis[1-(5-tert-butyl-2-methoxyphenyl)-2-hydroxyethyl]-2,2-dimethylmalonamide; With methanesulfonyl chloride; triethylamine; In dichloromethane; at 20 ℃; for 12h;

With potassium hydroxide; In methanol; for 2h; Heating;

DOI:10.1021/ol048179w

Reference yield:

N,N'-bis[1-(5-tert-butyl-2-methoxyphenyl)-2-hydroxyethyl]-2,2-dimethylmalonamide (796042-60-9) → (S,S)-2,2'-isopropylidenebis[4-(5-tert-butyl-2-hydroxyphenyl)-2-oxazoline]

Guidance literature:

Multi-step reaction with 2 steps

1.1: Et₃N; MsCl / CH₂Cl₂ / 12 h / 20 °C

1.2: 85 percent / KOH / methanol / 2 h / Heating

2.1: 93 percent / AlCl₃; EtSH

With aluminium trichloride; methanesulfonyl chloride; triethylamine; ethanethiol; In dichloromethane;

DOI:10.1021/ol048179w

upstream raw materials:

2,2-Dimethylmalonyl chloride

Downstream raw materials:

(S,S)-2,2'-isopropylidenebis[4-(5-tert-butyl-2-methoxyphenyl)-2-oxazoline]