(7S,9AR)-TERT-BUTYL 7-(HYDROXYMETHYL)HEXAHYDRO-1H-PYRIDO[1,2-A]PYRAZINE-2(6H)-CARBOXYLATE

Base Information

• Chemical Name: (7S,9AR)-TERT-BUTYL 7-(HYDROXYMETHYL)HEXAHYDRO-1H-PYRIDO[1,2-A]PYRAZINE-2(6H)-CARBOXYLATE
• CAS No.: 179089-84-0
• Molecular Formula: C₁₄H₂₆N₂O₃
• Molecular Weight: 270.372
• Mol file: 179089-84-0.mol

Synonyms:2H-Pyrido[1,2-a]pyrazine-2-carboxylicacid, octahydro-7-(hydroxymethyl)-, 1,1-dimethylethyl ester, (7S-cis)-

Chemical Property of (7S,9AR)-TERT-BUTYL 7-(HYDROXYMETHYL)HEXAHYDRO-1H-PYRIDO[1,2-A]PYRAZINE-2(6H)-CARBOXYLATE

Chemical Property:

• PSA: 53.01000
• LogP: 1.18580

Purity/Quality:

98%min ^*data from raw suppliers

(7-S,9-ALPHA-R)-TERT-BUTYL 7-(HYDROXYMETHYL)HEXAHYDRO-1H-PYRIDO-[1,2-A]PYRAZINE-2(6H)-CARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (7S,9AR)-TERT-BUTYL 7-(HYDROXYMETHYL)HEXAHYDRO-1H-PYRIDO[1,2-A]PYRAZINE-2(6H)-CARBOXYLATE

There total 21 articles about (7S,9AR)-TERT-BUTYL 7-(HYDROXYMETHYL)HEXAHYDRO-1H-PYRIDO[1,2-A]PYRAZINE-2(6H)-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → (7S,9AS)-Cis-7-hydroxymethyl-2-(tert-butoxycarbonyl)-2,3,4,6,7,8,9,9a-octahydro-1H-pyrido[1,2-a]pyrazine (156856-50-7,179089-84-0)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂

In dichloromethane;

DOI:10.1016/S0960-894X(98)00108-5

Reference yield:

cis-(octahydropyrido[1,2-a]pyrazin-7-yl)methanol (145012-50-6,145012-51-7,433734-91-9) → (7S,9AS)-Cis-7-hydroxymethyl-2-(tert-butoxycarbonyl)-2,3,4,6,7,8,9,9a-octahydro-1H-pyrido[1,2-a]pyrazine (156856-50-7,179089-84-0)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂

In dichloromethane;

DOI:10.1016/S0960-894X(98)00108-5

Reference yield:

(7R,9aR)-7-Hydroxymethyl-octahydro-pyrido[1,2-a]pyrazine-2-carboxylic acid tert-butyl ester (179089-84-0) → (7S,9AS)-Cis-7-hydroxymethyl-2-(tert-butoxycarbonyl)-2,3,4,6,7,8,9,9a-octahydro-1H-pyrido[1,2-a]pyrazine (156856-50-7,179089-84-0)

Guidance literature:

DOI:10.1016/S0960-894X(98)00108-5

upstream raw materials:

(7R,9AS)-Trans-7-formyl-2-(tert-butoxycarbonyl)-2,3,4,6,7,8,9,9a-octahydro-1H-pyrido[1,2-a]pyrazine

di-tert-butyl dicarbonate

((7R,9aS)-octahydro-1H-pyrido[1,2-a]pyrazin-7-yl)methanol

(S)-2-cyano-5-dimethylcarbamoyl-2H-pyridine-1-carboxylic acid methyl ester

Downstream raw materials:

((7R,9aS)-octahydro-1H-pyrido[1,2-a]pyrazin-7-yl)methanol

(7R,9AS)-Trans-7-(hydroxymethyl)-2-(tert-butoxycarbonyl)-2,3,4,6,7,8,9,9a-octahydro-1H-pyrido[1,2-a]pyrazine

(7S,9AS)-Cis-7-hydroxymethyl-2-(tert-butoxycarbonyl)-2,3,4,6,7,8,9,9a-octahydro-1H-pyrido[1,2-a]pyrazine

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