2,2-difluoro-1-[(4S,5R)-4-fluoromethyl-5-(4-{6-[(3-fluoropropylamino)methyl]pyridin-3-yl}phenyl)-2,2-dimethyloxazolidin-3-yl]ethanone

Base Information

Chemical Name:2,2-difluoro-1-[(4S,5R)-4-fluoromethyl-5-(4-{6-[(3-fluoropropylamino)methyl]pyridin-3-yl}phenyl)-2,2-dimethyloxazolidin-3-yl]ethanone
CAS No.:1454907-09-5
Molecular Formula:C₂₃H₂₇F₄N₃O₂
Molecular Weight:453.48
Hs Code.:

Synonyms:2,2-difluoro-1-[(4S,5R)-4-fluoromethyl-5-(4-{6-[(3-fluoropropylamino)methyl]pyridin-3-yl}phenyl)-2,2-dimethyloxazolidin-3-yl]ethanone

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Chemical Property of 2,2-difluoro-1-[(4S,5R)-4-fluoromethyl-5-(4-{6-[(3-fluoropropylamino)methyl]pyridin-3-yl}phenyl)-2,2-dimethyloxazolidin-3-yl]ethanone

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Technology Process of 2,2-difluoro-1-[(4S,5R)-4-fluoromethyl-5-(4-{6-[(3-fluoropropylamino)methyl]pyridin-3-yl}phenyl)-2,2-dimethyloxazolidin-3-yl]ethanone

There total 6 articles about 2,2-difluoro-1-[(4S,5R)-4-fluoromethyl-5-(4-{6-[(3-fluoropropylamino)methyl]pyridin-3-yl}phenyl)-2,2-dimethyloxazolidin-3-yl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64068-31-1
3-fluoropropan-1-amine hydrochloride

: 1454907-08-4
methanesulfonic acid 5-{4-[(4S,5R)-3-(2,2-difluoroacetyl)-4-fluoromethyl-2,2-dimethyloxazolidin-5-yl]phenyl}pyridin-2-ylmethyl ester

: 1454907-09-5
2,2-difluoro-1-[(4S,5R)-4-fluoromethyl-5-(4-{6-[(3-fluoropropylamino)methyl]pyridin-3-yl}phenyl)-2,2-dimethyloxazolidin-3-yl]ethanone

Guidance literature:: 3-fluoropropan-1-amine hydrochloride; With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 0.5h;

methanesulfonic acid 5-{4-[(4S,5R)-3-(2,2-difluoroacetyl)-4-fluoromethyl-2,2-dimethyloxazolidin-5-yl]phenyl}pyridin-2-ylmethyl ester; In acetonitrile; at 20 ℃;

Reference yield:

: 1431551-88-0
(4S,5R)-4-(fluoromethyl)-5-(4-iodophenyl)-2,2-dimethyloxazolidine

: 1454907-09-5
2,2-difluoro-1-[(4S,5R)-4-fluoromethyl-5-(4-{6-[(3-fluoropropylamino)methyl]pyridin-3-yl}phenyl)-2,2-dimethyloxazolidin-3-yl]ethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

2.1: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 22 h / 90 °C / Inert atmosphere

3.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene; ethanol / 6 h / 90 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 0.5 h / 0 °C

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.5 h / 20 °C

5.2: 20 °C

With bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ethanol; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 1454906-86-5
2,2-difluoro-1-((4S,5R)-4-(fluoromethyl)-5-(4-iodophenyl)-2,2-dimethyloxazolidin-3-yl)ethanone

: 1454907-09-5
2,2-difluoro-1-[(4S,5R)-4-fluoromethyl-5-(4-{6-[(3-fluoropropylamino)methyl]pyridin-3-yl}phenyl)-2,2-dimethyloxazolidin-3-yl]ethanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 22 h / 90 °C / Inert atmosphere

2.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene; ethanol / 6 h / 90 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 0.5 h / 0 °C

4.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.5 h / 20 °C

4.2: 20 °C

With bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ethanol; dichloromethane; water; toluene; acetonitrile;