Methyl alpha-(1-methylethylidene)-2-oxo-3-[(2-phenylacetyl)amino]-1-azetidineacetate

Base Information

Chemical Name:Methyl alpha-(1-methylethylidene)-2-oxo-3-[(2-phenylacetyl)amino]-1-azetidineacetate
CAS No.:78625-07-7
Molecular Formula:C₁₇H₂₀N₂O₄
Molecular Weight:316.357
Hs Code.:
DSSTox Substance ID:DTXSID401135044
Nikkaji Number:J1.367.200H

Synonyms:SCHEMBL11382468;DTXSID401135044;78625-07-7;Methyl alpha-(1-methylethylidene)-2-oxo-3-[(2-phenylacetyl)amino]-1-azetidineacetate

Suppliers and Price of Methyl alpha-(1-methylethylidene)-2-oxo-3-[(2-phenylacetyl)amino]-1-azetidineacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl alpha-(1-methylethylidene)-2-oxo-3-[(2-phenylacetyl)amino]-1-azetidineacetate

Chemical Property:

XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:316.14230712
Heavy Atom Count:23
Complexity:517

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(=C(C(=O)OC)N1CC(C1=O)NC(=O)CC2=CC=CC=C2)C

Technology Process of Methyl alpha-(1-methylethylidene)-2-oxo-3-[(2-phenylacetyl)amino]-1-azetidineacetate

There total 6 articles about Methyl alpha-(1-methylethylidene)-2-oxo-3-[(2-phenylacetyl)amino]-1-azetidineacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: aluminum nickel

: 79056-39-6
1-(2'-methyl-1'-carbomethoxy)-propenyl-3-phenylacetamido-4-methylthio-2-azetidinone

: 78625-07-7
1-(1'-methoxycarbonyl-2'-methylprop-1-enyl)-3-phenylacetamidoazetidin-2-one

Guidance literature:: In acetone;

Reference yield:

: 55826-28-3,55870-59-2,64838-98-8,64838-99-9,79056-39-6
3-Methyl-2-((2R,3S)-2-methylsulfanyl-4-oxo-3-phenylacetylamino-azetidin-1-yl)-but-2-enoic acid methyl ester

: 78625-07-7
1-(1'-methoxycarbonyl-2'-methylprop-1-enyl)-3-phenylacetamidoazetidin-2-one

Guidance literature:: With nickel; In acetone; for 0.333333h; Heating;
DOI:10.1016/S0040-4020(01)88885-2

Reference yield:

: 35859-85-9
3-Methyl-2-methylsulfanylmethyleneamino-but-2-enoic acid methyl ester

: 78625-07-7
1-(1'-methoxycarbonyl-2'-methylprop-1-enyl)-3-phenylacetamidoazetidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Et₃N, ethyl chloroformate, 2.) Et₃N / 1.) ether, -25 deg C, 15 min, 2.) ether-CH₂Cl₂, 3 h, 0 deg C then 10-12 h at room temp.

2: water, p-toluenesulfonic acid monohydrate / acetone

3: 67 percent / triethylamine / CH₂Cl₂ / 0 °C

4: 35 mg / activated Raney Ni / acetone / 0.33 h / Heating

With water; chloroformic acid ethyl ester; nickel; toluene-4-sulfonic acid; triethylamine; In dichloromethane; acetone;
DOI:10.1016/S0040-4020(01)88885-2