(S)-methyl 2-((4-carbamoyl-6-(4-(4-fluorophenoxy)phenyl)pyrimidin-2-yl)amino)propanoate

Base Information

Chemical Name:(S)-methyl 2-((4-carbamoyl-6-(4-(4-fluorophenoxy)phenyl)pyrimidin-2-yl)amino)propanoate
CAS No.:1426337-20-3
Molecular Formula:C₂₁H₁₉FN₄O₄
Molecular Weight:410.405
Hs Code.:

Synonyms:(S)-methyl 2-((4-carbamoyl-6-(4-(4-fluorophenoxy)phenyl)pyrimidin-2-yl)amino)propanoate

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Chemical Property of (S)-methyl 2-((4-carbamoyl-6-(4-(4-fluorophenoxy)phenyl)pyrimidin-2-yl)amino)propanoate

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Technology Process of (S)-methyl 2-((4-carbamoyl-6-(4-(4-fluorophenoxy)phenyl)pyrimidin-2-yl)amino)propanoate

There total 4 articles about (S)-methyl 2-((4-carbamoyl-6-(4-(4-fluorophenoxy)phenyl)pyrimidin-2-yl)amino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1355052-34-4
2-(4-(4-fluorophenoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1426337-08-7
(S)-methyl 2-((4-carbamoyl-6-chloropyrimidin-2-yl)amino)propanoate

: 1426337-20-3
(S)-methyl 2-((4-carbamoyl-6-(4-(4-fluorophenoxy)phenyl)pyrimidin-2-yl)amino)propanoate

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In 1,4-dioxane; water; at 80 ℃; for 5h; Inert atmosphere; Sealed tube;

Reference yield:

: 26830-94-4
2,4-dichloropyrimidine-6-carboxylic acid chloride

: 1426337-20-3
(S)-methyl 2-((4-carbamoyl-6-(4-(4-fluorophenoxy)phenyl)pyrimidin-2-yl)amino)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: ammonia; N-ethyl-N,N-diisopropylamine / diethyl ether; 1,4-dioxane

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 50 °C

3: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 5 h / 80 °C / Inert atmosphere; Sealed tube

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; ammonia; sodium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; diethyl ether; water; acetonitrile;

Reference yield:

: 65-86-1,58915-47-2,6784-70-9
orotic acid

: 1426337-20-3
(S)-methyl 2-((4-carbamoyl-6-(4-(4-fluorophenoxy)phenyl)pyrimidin-2-yl)amino)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate; N,N-dimethyl-formamide / 110 °C

2: ammonia; N-ethyl-N,N-diisopropylamine / diethyl ether; 1,4-dioxane

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 50 °C

4: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 5 h / 80 °C / Inert atmosphere; Sealed tube

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; ammonia; sodium carbonate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trichlorophosphate; In 1,4-dioxane; diethyl ether; water; acetonitrile;