(E)-3-(4-tert-butylphenyl)acrylic acid n-butyl ester

Base Information

• Chemical Name: (E)-3-(4-tert-butylphenyl)acrylic acid n-butyl ester
• CAS No.: 1265015-19-7
• Molecular Formula: C₁₇H₂₄O₂
• Molecular Weight: 260.376
• Mol file: 1265015-19-7.mol

Synonyms:(E)-3-(4-tert-butylphenyl)acrylic acid n-butyl ester

Chemical Property of (E)-3-(4-tert-butylphenyl)acrylic acid n-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (E)-3-(4-tert-butylphenyl)acrylic acid n-butyl ester

There total 6 articles about (E)-3-(4-tert-butylphenyl)acrylic acid n-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

acrylic acid n-butyl ester (141-32-2,9003-49-0) + p-tert-butylphenylboronic acid (123324-71-0) → (E)-3-(4-tert-butylphenyl)acrylic acid n-butyl ester (1265015-19-7)

Guidance literature:

With C₄₈H₄₀N₄O₄Pd₂⁽⁴⁺⁾; trifluoroacetic acid; p-benzoquinone; In water; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1002/adsc.201500220

Reference yield: 87.0%

1-allyl-4-(tert-butyl)benzene (27798-45-4) + butan-1-ol (71-36-3) → (E)-3-(4-tert-butylphenyl)acrylic acid n-butyl ester (1265015-19-7)

Guidance literature:

With water; oxygen; palladium diacetate; In N,N-dimethyl acetamide; at 100 ℃; for 24h; under 760.051 Torr; chemoselective reaction; Schlenk technique;

DOI:10.1039/c5cc02277k

Reference yield: 81.0%

acrylic acid n-butyl ester (141-32-2,9003-49-0) + 1-bromo-4-tert-butylbenzene (3972-65-4) → (E)-3-(4-tert-butylphenyl)acrylic acid n-butyl ester (1265015-19-7)

Guidance literature:

With 1-methyl-pyrrolidin-2-one; sodium acetate; at 120 - 140 ℃; for 15h; stereoselective reaction; Inert atmosphere;

DOI:10.1002/hlca.201000412

upstream raw materials:

4-tert-butylbenzenesulfonyl chloride

acrylic acid n-butyl ester

1-bromo-4-tert-butylbenzene

p-tert-butylphenylboronic acid

Refernces

• 1、 Silarska,Trzeciak. "Oxygen-promoted coupling of arylboronic acids with olefins catalyzed by [CA]2[PdX4] complexes without a base". . p. 1 - 11. Retrieved 2015/07/28.
• 2、 Mi, Xia,Huang, Mengmeng,Guo, Hai,Wu, Yangjie. "An efficient palladium(II) catalyst for oxidative Heck-type reaction under base-free conditions". . p. 5123 - 5128. Retrieved 2013/06/27.