N-{5-Chloro-4-[(4-chloro-phenyl)-cyano-methyl]-2-methyl-phenyl}-2-methoxy-3,5-bis-trifluoromethyl-benzamide

Base Information

• Chemical Name: N-{5-Chloro-4-[(4-chloro-phenyl)-cyano-methyl]-2-methyl-phenyl}-2-methoxy-3,5-bis-trifluoromethyl-benzamide
• CAS No.: 212135-72-3
• Molecular Formula: C₂₅H₁₆Cl₂F₆N₂O₂
• Molecular Weight: 561.311

Synonyms:N-{5-Chloro-4-[(4-chloro-phenyl)-cyano-methyl]-2-methyl-phenyl}-2-methoxy-3,5-bis-trifluoromethyl-benzamide

Chemical Property of N-{5-Chloro-4-[(4-chloro-phenyl)-cyano-methyl]-2-methyl-phenyl}-2-methoxy-3,5-bis-trifluoromethyl-benzamide

Chemical Property:

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Technology Process of N-{5-Chloro-4-[(4-chloro-phenyl)-cyano-methyl]-2-methyl-phenyl}-2-methoxy-3,5-bis-trifluoromethyl-benzamide

There total 2 articles about N-{5-Chloro-4-[(4-chloro-phenyl)-cyano-methyl]-2-methyl-phenyl}-2-methoxy-3,5-bis-trifluoromethyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Methoxy-3,5-bis-trifluoromethyl-benzoic acid (197015-74-0) → N-{5-Chloro-4-[(4-chloro-phenyl)-cyano-methyl]-2-methyl-phenyl}-2-methoxy-3,5-bis-trifluoromethyl-benzamide (212135-72-3)

Guidance literature:

Multi-step reaction with 2 steps

1: (COCl)2, DMF / tetrahydrofuran / 1 h / Ambient temperature

2: pyridine / tetrahydrofuran / 2 h / Ambient temperature

With pyridine; oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran;

DOI:10.1021/jm9803572

Reference yield:

2-(4-amino-2-chloro-5-methylphenyl)-2-(4-chlorophenyl)acetonitrile (61437-85-2) + 2-Methoxy-3,5-bis-trifluoromethyl-benzoyl chloride → N-{5-Chloro-4-[(4-chloro-phenyl)-cyano-methyl]-2-methyl-phenyl}-2-methoxy-3,5-bis-trifluoromethyl-benzamide (212135-72-3)

Guidance literature:

With pyridine; In tetrahydrofuran; for 2h; Yield given; Ambient temperature;

DOI:10.1021/jm9803572

Reference yield: 73.0%

N-{5-Chloro-4-[(4-chloro-phenyl)-cyano-methyl]-2-methyl-phenyl}-2-methoxy-3,5-bis-trifluoromethyl-benzamide (212135-72-3) → N-{5-Chloro-4-[(4-chloro-phenyl)-cyano-methyl]-2-methyl-phenyl}-2-hydroxy-3,5-bis-trifluoromethyl-benzamide

Guidance literature:

With boron tribromide; In dichloromethane; for 3h; Ambient temperature;

DOI:10.1021/jm9803572

upstream raw materials:

2-(4-amino-2-chloro-5-methylphenyl)-2-(4-chlorophenyl)acetonitrile

2-Methoxy-3,5-bis-trifluoromethyl-benzoic acid

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