(4-tert-butyl-2,6-dimethylphenyl)(2,6-dibromo-4-ethynylphenyl)methanone

Base Information

Chemical Name:(4-tert-butyl-2,6-dimethylphenyl)(2,6-dibromo-4-ethynylphenyl)methanone
CAS No.:763110-69-6
Molecular Formula:C₂₁H₂₀Br₂O
Molecular Weight:448.197
Hs Code.:

Synonyms:(4-tert-butyl-2,6-dimethylphenyl)(2,6-dibromo-4-ethynylphenyl)methanone

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Chemical Property of (4-tert-butyl-2,6-dimethylphenyl)(2,6-dibromo-4-ethynylphenyl)methanone

Chemical Property:

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Technology Process of (4-tert-butyl-2,6-dimethylphenyl)(2,6-dibromo-4-ethynylphenyl)methanone

There total 5 articles about (4-tert-butyl-2,6-dimethylphenyl)(2,6-dibromo-4-ethynylphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 763110-68-5
(4-tert-butyl-2,6-dimetgylphenyl)[2,6-dibromo-4-(trimethylsilylethynyl)phenyl]methanone

: 763110-69-6
(4-tert-butyl-2,6-dimethylphenyl)(2,6-dibromo-4-ethynylphenyl)methanone

Guidance literature:: With sodium hydroxide; In tert-butyl alcohol; at 20 ℃;
DOI:10.1002/ejoc.200400123

Reference yield:

: 5345-05-1
4-t-butyl-2,6-dimethylbromobenzene

: 763110-69-6
(4-tert-butyl-2,6-dimethylphenyl)(2,6-dibromo-4-ethynylphenyl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: magnesium ribbon; iodine / diethyl ether / Heating

1.2: 36 percent / tetrahydrofuran; diethyl ether / 5 h / Heating

2.1: 71 percent / chromium(IV) oxide; cc. sulfuric acid / H₂O; acetone / 3 h

3.1: 56 percent / copper(I) iodide / bis(triphenylphosphane)palladium dichloride / triethylamine

4.1: 98 percent / aq. NaOH / 2-methyl-propan-2-ol / 20 °C

With sodium hydroxide; copper(l) iodide; chromium (VI) oxide; sulfuric acid; iodine; magnesium; bis-triphenylphosphine-palladium(II) chloride; In diethyl ether; water; triethylamine; acetone; tert-butyl alcohol; 3.1: Sonogashira coupling reaction;
DOI:10.1002/ejoc.200400123

Reference yield:

: 45859-98-1
2,4,6-tribromobenzaldehyde

: 763110-69-6
(4-tert-butyl-2,6-dimethylphenyl)(2,6-dibromo-4-ethynylphenyl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: magnesium ribbon; iodine / diethyl ether / Heating

1.2: 36 percent / tetrahydrofuran; diethyl ether / 5 h / Heating

2.1: 71 percent / chromium(IV) oxide; cc. sulfuric acid / H₂O; acetone / 3 h

3.1: 56 percent / copper(I) iodide / bis(triphenylphosphane)palladium dichloride / triethylamine

4.1: 98 percent / aq. NaOH / 2-methyl-propan-2-ol / 20 °C

With sodium hydroxide; copper(l) iodide; chromium (VI) oxide; sulfuric acid; iodine; magnesium; bis-triphenylphosphine-palladium(II) chloride; In diethyl ether; water; triethylamine; acetone; tert-butyl alcohol; 3.1: Sonogashira coupling reaction;
DOI:10.1002/ejoc.200400123