6-CHLORO-[1,2,4]TRIAZOLO[3,4-A]PHTHALAZINE

Base Information

• Chemical Name: 6-CHLORO-[1,2,4]TRIAZOLO[3,4-A]PHTHALAZINE
• CAS No.: 52494-53-8
• Molecular Formula: C9H5ClN4
• Molecular Weight: 204.619
• Hs Code.: 2933990090
• Mol file: 52494-53-8.mol

Synonyms:NSC 228171;

Chemical Property of 6-CHLORO-[1,2,4]TRIAZOLO[3,4-A]PHTHALAZINE

Chemical Property:

• Refractive Index: 1.803
• PSA: 43.08000
• Density: 1.62 g/cm³
• LogP: 1.93090

Purity/Quality:

97% ^*data from raw suppliers

6-Chloro[1,2,4]triazolo[3,4-A]phthalazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-CHLORO-[1,2,4]TRIAZOLO[3,4-A]PHTHALAZINE

There total 1 articles about 6-CHLORO-[1,2,4]TRIAZOLO[3,4-A]PHTHALAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phthalic anhydride (85-44-9) → 6-chloro-1,2,4-triazolo<3,4-a>phthalazine (52494-53-8)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrazine hydrate / acetic acid / 4 h / 120 °C

2: trichlorophosphate / 1 h / 110 °C

3: hydrazine hydrate / ethanol / 0.5 h / Reflux

4: triethylamine / 1,4-dioxane / 110 °C

With hydrazine hydrate; triethylamine; trichlorophosphate; In 1,4-dioxane; ethanol; acetic acid;

DOI:10.1016/j.bmcl.2013.12.010

Reference yield: 91.0%

6-chloro-1,2,4-triazolo<3,4-a>phthalazine (52494-53-8) + 2-Chlorobenzyl alcohol (17849-38-6) → 6-(2-chlorobenzyloxy)-[1,2,4]triazolo[3,4-a]phthalazine (1447735-48-9)

Guidance literature:

With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; In acetonitrile; for 3h; Reflux;

DOI:10.3109/14756366.2012.684052

Reference yield: 90.0%

6-chloro-1,2,4-triazolo<3,4-a>phthalazine (52494-53-8) + m-chlorobenzyl alcohol (873-63-2) → 6-(3-chlorobenzyloxy)-[1,2,4]triazolo[3,4-a]phthalazine (1447735-49-0)

Guidance literature:

With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; In acetonitrile; for 3h; Reflux;

DOI:10.3109/14756366.2012.684052

upstream raw materials:

phthalic anhydride

Downstream raw materials:

6-(4-benzylpiperazin-1-yl)-[1,2,4]triazolo[3,4-a]phthalazine