(-)-3-methyl-2-<(phenylsulfonyl)methyl>butyl chloroacetate

Base Information

• Chemical Name: (-)-3-methyl-2-<(phenylsulfonyl)methyl>butyl chloroacetate
• CAS No.: 152615-06-0
• Molecular Formula: C₁₄H₁₉ClO₄S
• Molecular Weight: 318.821
• Mol file: 152615-06-0.mol

Synonyms:(-)-3-methyl-2-<(phenylsulfonyl)methyl>butyl chloroacetate

Chemical Property of (-)-3-methyl-2-<(phenylsulfonyl)methyl>butyl chloroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-3-methyl-2-<(phenylsulfonyl)methyl>butyl chloroacetate

There total 6 articles about (-)-3-methyl-2-<(phenylsulfonyl)methyl>butyl chloroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenylthiomethyl chloride (7205-91-6) → (-)-3-methyl-2-<(phenylsulfonyl)methyl>butyl chloroacetate (152615-06-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 66 percent / zinc bromide / CH₂Cl₂ / 48 h / Ambient temperature

2: 97 percent / lithium aluminum hydride / tetrahydrofuran / 5 h / 0 °C

3: 97 percent / benzeneselenic acid, 30percent hydrogen peroxide / CH₂Cl₂ / 60 h / Ambient temperature

4: 82 percent / triethylamine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 6 h / 0 °C

With dmap; lithium aluminium tetrahydride; benzeneseleninic acid; dihydrogen peroxide; triethylamine; zinc dibromide; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0957-4166(00)80137-8

Reference yield:

3-methyl-1-methoxy-1-trimethylsilyloxy-1-butene (84393-13-5) → (-)-3-methyl-2-<(phenylsulfonyl)methyl>butyl chloroacetate (152615-06-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 66 percent / zinc bromide / CH₂Cl₂ / 48 h / Ambient temperature

2: 97 percent / lithium aluminum hydride / tetrahydrofuran / 5 h / 0 °C

3: 97 percent / benzeneselenic acid, 30percent hydrogen peroxide / CH₂Cl₂ / 60 h / Ambient temperature

4: 82 percent / triethylamine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 6 h / 0 °C

With dmap; lithium aluminium tetrahydride; benzeneseleninic acid; dihydrogen peroxide; triethylamine; zinc dibromide; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0957-4166(00)80137-8

Reference yield:

3-methyl-2-<(phenylthio)methyl>-1-butanol (152615-03-7) → (-)-3-methyl-2-<(phenylsulfonyl)methyl>butyl chloroacetate (152615-06-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / benzeneselenic acid, 30percent hydrogen peroxide / CH₂Cl₂ / 60 h / Ambient temperature

2: 82 percent / triethylamine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 6 h / 0 °C

With dmap; benzeneseleninic acid; dihydrogen peroxide; triethylamine; In dichloromethane;

DOI:10.1016/S0957-4166(00)80137-8

upstream raw materials:

3-methyl-2-<(phenylsulfonyl)methyl>butyl chloroacetate

phenylthiomethyl chloride

3-methyl-1-methoxy-1-trimethylsilyloxy-1-butene

3-methyl-2-<(phenylthio)methyl>-1-butanol

Downstream raw materials:

(S)-3-methyl-2-((phenylsulfonyl)methyl)butan-1-ol

(S)-(-)-3-methyl-2-<(phenylsulfonyl)methyl>butyl phenyl sulfide