2-Piperazin-1-yl-benzothiazole

Base Information

• Chemical Name: 2-Piperazin-1-yl-benzothiazole
• CAS No.: 55745-83-0
• Molecular Formula: C11H13N3S
• Molecular Weight: 219.31
• Hs Code.: 2934200090
• Mol file: 55745-83-0.mol

Synonyms:1-(2-Benzothiazolyl)piperazine;2-(Piperazin-1-yl)benzothiazole;

Chemical Property of 2-Piperazin-1-yl-benzothiazole

Chemical Property:

• Vapor Pressure: 1.1E-05mmHg at 25°C
• Melting Point: 75-79℃
• Refractive Index: 1.655
• Boiling Point: 370.5 °C at 760 mmHg
• PKA: 8.33±0.10(Predicted)
• Flash Point: 177.9 °C
• PSA: 56.40000
• Density: 1.256g/cm³
• LogP: 2.09970
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99%, ^*data from raw suppliers

2-Piperazin-1-yl-benzothiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(1-Piperazinyl)benzothiazole is a useful compound in the study of 1,8-Naphthyridone derivatives as potential inhibitor of HIV-1 replication.

Technology Process of 2-Piperazin-1-yl-benzothiazole

There total 16 articles about 2-Piperazin-1-yl-benzothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-benzothiazol-2-yl-piperazine-1-carboxylic acid tert-butyl ester → 2-piperazinobenzothiazole (55745-83-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 3h;

DOI:10.1016/j.ejmech.2020.112721

Reference yield: 96.0%

ethyl 4-(benzothiazol-2-yl)-piperazin-1-carboxylate (232263-41-1) → 2-piperazinobenzothiazole (55745-83-0)

Guidance literature:

With hydrogen bromide; In water; at 70 ℃; for 24h;

DOI:10.1016/j.bmcl.2013.07.047

Reference yield: 95.0%

piperazine (110-85-0) + 2-chlorobenzo[d][1,3]thiazole (615-20-3) → 2-piperazinobenzothiazole (55745-83-0)

Guidance literature:

With potassium tert-butylate; C₆₆H₉₂Cl₃N₃Pd; In n-heptane; at 100 ℃; for 4h;

DOI:10.1002/chem.202103341

upstream raw materials:

piperazine

2-chlorobenzo[d][1,3]thiazole

2-methanesulfonylbenzothiazole

3-(1-piperazinyl)-1,2-benzisothiazole

Downstream raw materials:

2-[4-(4-chloro-phenyl)-piperazin-1-yl]-benzothiazole

1-benzothiazol-2-yl-4-[3-(4-methoxy-phenyl)-acryloyl]-piperazine

C₂₂H₂₇N₃O₂S₂

9-[4-(4-benzothiazol-2-yl-piperazin-1-yl)-butyl]-9H-fluorene-9-carboxylic Acid-4-fluoro-benzylamide

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