(4R,5R)-5-[(diphenyl)(sulfanyl)methyl]-α,α,2,2-tetraphenyl-1,3-dioxolane-4-methanol

Base Information

Chemical Name:(4R,5R)-5-[(diphenyl)(sulfanyl)methyl]-α,α,2,2-tetraphenyl-1,3-dioxolane-4-methanol
CAS No.:1400792-59-7
Molecular Formula:C₄₁H₃₄O₃S
Molecular Weight:606.785
Hs Code.:

Synonyms:(4R,5R)-5-[(diphenyl)(sulfanyl)methyl]-α,α,2,2-tetraphenyl-1,3-dioxolane-4-methanol

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Chemical Property of (4R,5R)-5-[(diphenyl)(sulfanyl)methyl]-α,α,2,2-tetraphenyl-1,3-dioxolane-4-methanol

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Technology Process of (4R,5R)-5-[(diphenyl)(sulfanyl)methyl]-α,α,2,2-tetraphenyl-1,3-dioxolane-4-methanol

There total 2 articles about (4R,5R)-5-[(diphenyl)(sulfanyl)methyl]-α,α,2,2-tetraphenyl-1,3-dioxolane-4-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1400792-52-0
(4R,5R)-5-[(chloro)(diphenyl)methyl]-α,α,2,2-tetraphenyl-1,3-dioxolane-4-methanol

: 1400792-59-7
(4R,5R)-5-[(diphenyl)(sulfanyl)methyl]-α,α,2,2-tetraphenyl-1,3-dioxolane-4-methanol

Guidance literature:: (4R,5R)-5-[(chloro)(diphenyl)methyl]-α,α,2,2-tetraphenyl-1,3-dioxolane-4-methanol; With thiourea; In N,N-dimethyl-formamide; at 20 ℃; for 72h;

With sodium hydroxide; In diethyl ether; N,N-dimethyl-formamide; for 1h;
DOI:10.1002/hlca.201200146

Reference yield:

: 126524-74-1
(4R,5R)-2,2-diphenyl-α,α,α',α'-tetraphenyl-1,3-dioxolane-4,5-dimethanol

: 1400792-59-7
(4R,5R)-5-[(diphenyl)(sulfanyl)methyl]-α,α,2,2-tetraphenyl-1,3-dioxolane-4-methanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine; tetrachloromethane; triphenylphosphine / dichloromethane / 120 h / 20 °C

2.1: thiourea / N,N-dimethyl-formamide / 72 h / 20 °C

2.2: 1 h

With pyridine; tetrachloromethane; thiourea; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; 1.1: Appel reaction;
DOI:10.1002/hlca.201200146

Reference yield: 55.0%

: 1400792-59-7
(4R,5R)-5-[(diphenyl)(sulfanyl)methyl]-α,α,2,2-tetraphenyl-1,3-dioxolane-4-methanol

: copper(l) chloride

: tetrakis[μ-(4R,5R)-5-[(diphenyl)(sulfanyl-κS,κS)methyl]-α,α,2,2-tetraphenyl-1,3-dioxolane-4-methanolato(1-)]tetracopper(I)

Guidance literature:: With N(CH₂CH₃)3; In methanol; addn. of triethylamine to methanolic suspn. of thiol with stirring at room temp., addn. of CuCl, refluxing for 10 min; concg., filtration, dissolving in CH2Cl2, chromy. (SiO2, pentane/diethylether (1:1)), elem. anal.;
DOI:10.1002/hlca.201200146