2-PIPERAZIN-1-YL-BENZOOXAZOLE

Base Information

• Chemical Name: 2-PIPERAZIN-1-YL-BENZOOXAZOLE
• CAS No.: 111628-39-8
• Molecular Formula: C11H13N3O
• Molecular Weight: 203.244
• Hs Code.: 2934999090
• Mol file: 111628-39-8.mol

Synonyms:1-(2-Benzoxazolyl)piperazine;2-(1-Piperazinyl)benzoxazole;2-Piperazinobenzoxazole;Benzoxazole, 2-(1-piperazinyl)-;

Chemical Property of 2-PIPERAZIN-1-YL-BENZOOXAZOLE

Chemical Property:

• Vapor Pressure: 6.29E-05mmHg at 25°C
• Melting Point: 68-70 °C
• Refractive Index: 1.607
• Boiling Point: 345.1 °C at 760 mmHg
• PKA: 8.55±0.10(Predicted)
• Flash Point: 162.5 °C
• PSA: 41.30000
• Density: 1.21 g/cm³
• LogP: 1.63120
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99%, ^*data from raw suppliers

2-Piperazin-1-yl-1,3-benzoxazole ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-PIPERAZIN-1-YL-BENZOOXAZOLE

There total 7 articles about 2-PIPERAZIN-1-YL-BENZOOXAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

tert-butyl 4-(benzo[d]oxazol-2-yl)piperazine-1-carboxylate (195390-64-8) → 2-(1-piperazinyl)-1,3-benzoxazole (111628-39-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 3h;

DOI:10.1016/j.ejmech.2020.112721

Reference yield: 88.3%

piperazine (110-85-0) + 2-chloro-1,3-benzoxazole (615-18-9) → 2-(1-piperazinyl)-1,3-benzoxazole (111628-39-8)

Guidance literature:

In dichloromethane; at 20 - 25 ℃; for 17h; Inert atmosphere;

DOI:10.1021/acs.oprd.6b00104

Reference yield: 75.0%

piperazine (110-85-0) + benzoxazole (273-53-0,29791-96-6) → 2-(1-piperazinyl)-1,3-benzoxazole (111628-39-8)

Guidance literature:

With oxygen; acetic acid; In acetonitrile; at 70 ℃; for 12h;

DOI:10.1039/d0nj02385j

upstream raw materials:

piperazine

2-chloro-1,3-benzoxazole

2-amino-phenol

2-sulfanyl-1,3-benzoxazole

Downstream raw materials:

(2R,3R)-3-(4-(benzooxazol-2-yl)piperazin-1-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

C₃₉H₄₄FN₅O₄

2-(4-(3-(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-ylthio)propyl)piperazin-1-yl)benzo[d]oxazole

2-(4-(3-(5-(4-nitrophenyl)-1,3,4-oxadiazol-2-ylthio)propyl)piperazin-1-yl)benzo[d]oxazole

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