N-(3-(2-amino-1-(1H-pyrrole-2-carbonyl)-1H-imidazol-4-yl)phenyl)-1H-pyrrole-2-carboxamide

Base Information

Chemical Name:N-(3-(2-amino-1-(1H-pyrrole-2-carbonyl)-1H-imidazol-4-yl)phenyl)-1H-pyrrole-2-carboxamide
CAS No.:1574306-19-6
Molecular Formula:C₁₉H₁₆N₆O₂
Molecular Weight:360.375
Hs Code.:

Synonyms:N-(3-(2-amino-1-(1H-pyrrole-2-carbonyl)-1H-imidazol-4-yl)phenyl)-1H-pyrrole-2-carboxamide

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Chemical Property of N-(3-(2-amino-1-(1H-pyrrole-2-carbonyl)-1H-imidazol-4-yl)phenyl)-1H-pyrrole-2-carboxamide

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Technology Process of N-(3-(2-amino-1-(1H-pyrrole-2-carbonyl)-1H-imidazol-4-yl)phenyl)-1H-pyrrole-2-carboxamide

There total 4 articles about N-(3-(2-amino-1-(1H-pyrrole-2-carbonyl)-1H-imidazol-4-yl)phenyl)-1H-pyrrole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1190433-51-2
4-(3-aminophenyl)-1H-imidazol-2-amine

: 634-97-9
pyrrole-2-carboxyl acid

: 1574306-19-6
N-(3-(2-amino-1-(1H-pyrrole-2-carbonyl)-1H-imidazol-4-yl)phenyl)-1H-pyrrole-2-carboxamide

Guidance literature:: pyrrole-2-carboxyl acid; With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

4-(3-aminophenyl)-1H-imidazol-2-amine; In N,N-dimethyl-formamide; at 20 ℃; for 15h;
DOI:10.1016/j.ejmech.2013.12.034

Reference yield:

: 76507-17-0
4-(3-nitrophenyl)-1H-imidazol-2-amine

: 1574306-19-6
N-(3-(2-amino-1-(1H-pyrrole-2-carbonyl)-1H-imidazol-4-yl)phenyl)-1H-pyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: palladium on activated charcoal; hydrogen / tetrahydrofuran / 5 h / 20 °C

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 15 h / 20 °C

With 4-methyl-morpholine; palladium on activated charcoal; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2013.12.034

Reference yield:

: 2227-64-7
3'-nitro-2-bromoacetophenone

: 1574306-19-6
N-(3-(2-amino-1-(1H-pyrrole-2-carbonyl)-1H-imidazol-4-yl)phenyl)-1H-pyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap / acetonitrile / 5 h / 20 °C

2.1: hydrazine hydrate / ethyl [2]alcohol / 0.67 h / 120 °C / Microwave irradiation

3.1: palladium on activated charcoal; hydrogen / tetrahydrofuran / 5 h / 20 °C

4.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.5 h / 20 °C

4.2: 15 h / 20 °C

With 4-methyl-morpholine; dmap; palladium on activated charcoal; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; hydrazine hydrate; In tetrahydrofuran; ethyl [2]alcohol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.ejmech.2013.12.034