(2R,2'R,4S)-methyl 2-(tert-butyl)-3'-<(1',2',3',4'-tetrahydro-4-oxo-2'-phenylpyridin-1'-yl)carbonyl>-1,3-oxazolidine-4-carboxylate

Base Information

Chemical Name:(2R,2'R,4S)-methyl 2-(tert-butyl)-3'-<(1',2',3',4'-tetrahydro-4-oxo-2'-phenylpyridin-1'-yl)carbonyl>-1,3-oxazolidine-4-carboxylate
CAS No.:168105-12-2
Molecular Formula:C₂₁H₂₆N₂O₅
Molecular Weight:386.448
Hs Code.:

Synonyms:(2R,2'R,4S)-methyl 2-(tert-butyl)-3'-<(1',2',3',4'-tetrahydro-4-oxo-2'-phenylpyridin-1'-yl)carbonyl>-1,3-oxazolidine-4-carboxylate

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Chemical Property of (2R,2'R,4S)-methyl 2-(tert-butyl)-3'-<(1',2',3',4'-tetrahydro-4-oxo-2'-phenylpyridin-1'-yl)carbonyl>-1,3-oxazolidine-4-carboxylate

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Technology Process of (2R,2'R,4S)-methyl 2-(tert-butyl)-3'-<(1',2',3',4'-tetrahydro-4-oxo-2'-phenylpyridin-1'-yl)carbonyl>-1,3-oxazolidine-4-carboxylate

There total 2 articles about (2R,2'R,4S)-methyl 2-(tert-butyl)-3'-<(1',2',3',4'-tetrahydro-4-oxo-2'-phenylpyridin-1'-yl)carbonyl>-1,3-oxazolidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: phenylmagnesium bromide

: 1-((2R,4S)-2-tert-Butyl-4-methoxycarbonyl-oxazolidine-3-carbonyl)-4-methoxy-pyridinium; chloride

: 168105-12-2
(2R,2'R,4S)-methyl 2-(tert-butyl)-3'-<(1',2',3',4'-tetrahydro-4-oxo-2'-phenylpyridin-1'-yl)carbonyl>-1,3-oxazolidine-4-carboxylate

Guidance literature:: In diethyl ether; toluene; Yield given; 0 deg C, then room temp., 30 min.;
DOI:10.1002/hlca.19950780106

Reference yield:

: 620-08-6,1232006-56-2
4-methoxypyridine

: phenylmagnesium bromide

: 1-((2R,4S)-2-tert-Butyl-4-methoxycarbonyl-oxazolidine-3-carbonyl)-4-methoxy-pyridinium; iodide

: (2R,4S)-2-tert-Butyl-3-((R)-4-oxo-2-phenyl-3,4-dihydro-2H-pyridine-1-carbonyl)-oxazolidine-4-carboxylic acid methyl ester

: 168105-12-2
(2R,2'R,4S)-methyl 2-(tert-butyl)-3'-<(1',2',3',4'-tetrahydro-4-oxo-2'-phenylpyridin-1'-yl)carbonyl>-1,3-oxazolidine-4-carboxylate

Guidance literature:: With hydrogenchloride; sodium iodide; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1016/S0040-4039(00)76704-9

Reference yield: 96.0%

: 168105-12-2
(2R,2'R,4S)-methyl 2-(tert-butyl)-3'-<(1',2',3',4'-tetrahydro-4-oxo-2'-phenylpyridin-1'-yl)carbonyl>-1,3-oxazolidine-4-carboxylate

: 157379-62-9
(2R)-2,3-dihydro-2-phenylpyridin-4(1H)-one

Guidance literature:: With hydrogenchloride; sodium hydroxide; In water; Ambient temperature; 1.) room temp., overnight; 2.) pH 12, 2 h;
DOI:10.1002/hlca.19950780106