5-Chloro-2,4-difluoro-6-methylpyrimidine

Base Information

Chemical Name:5-Chloro-2,4-difluoro-6-methylpyrimidine
CAS No.:72630-78-5
Molecular Formula:C₅H₃ClF₂N₂
Molecular Weight:164.542
Hs Code.:2933599590
European Community (EC) Number:921-626-9
DSSTox Substance ID:DTXSID30515576
Wikidata:Q82376509
Mol file:72630-78-5.mol

Synonyms:5-chloro-2,4-difluoro-6-methylpyrimidine;72630-78-5;5-Chloro-2,4-difluoro-6-methyl-pyrimidine;Pyrimidine,5-chloro-2,4-difluoro-6-methyl-;SCHEMBL8947552;DTXSID30515576;1-Boc-4-Hydroxy-L-prolineethylester;MFCD00036058;AKOS006345917;SB55922;CS-0455295;FT-0664626;A837582;5-chloranyl-2,4-bis(fluoranyl)-6-methyl-pyrimidine;W-203641;5-chloro-2,4-difluoro-6-methyl-pyrimidine, AldrichCPR

Suppliers and Price of 5-Chloro-2,4-difluoro-6-methylpyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
5-Chloro-2,4-difluoro-6-methylpyrimidine
250mg
$ 425.00

TRC
5-Chloro-2,4-difluoro-6-methylpyrimidine
500mg
$ 250.00

SynQuest Laboratories
5-Chloro-2,4-difluoro-6-methylpyrimidine 98%
1 g
$ 256.00

Medical Isotopes, Inc.
5-Chloro-2,4-difluoro-6-methylpyrimidine
1.25 g
$ 2000.00

Medical Isotopes, Inc.
5-Chloro-2,4-difluoro-6-methylpyrimidine
250 mg
$ 875.00

Crysdot
5-Chloro-2,4-difluoro-6-methylpyrimidine 97%
5g
$ 728.00

CHESS?
SG000450:5-Chloro-2,4-difluoro-6-methyl-pyrimidine 96
5 g
$ 180.00

Biosynth Carbosynth
5-Chloro-2,4-difluoro-6-methylpyrimidine
250 mg
$ 262.50

Biosynth Carbosynth
5-Chloro-2,4-difluoro-6-methylpyrimidine
100 mg
$ 137.00

Biosynth Carbosynth
5-Chloro-2,4-difluoro-6-methylpyrimidine
50 mg
$ 79.00

Total 16 raw suppliers

Chemical Property of 5-Chloro-2,4-difluoro-6-methylpyrimidine

Chemical Property:

Vapor Pressure:0.0155mmHg at 25°C
Melting Point:3 °C
Refractive Index:1.483
Boiling Point:264.9 °C at 760 mmHg
PKA:-3.22±0.39(Predicted)
Flash Point:114 °C
PSA：25.78000
Density:1.462 g/cm³
LogP:1.71660
XLogP3:2.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:0
Exact Mass:163.9952821
Heavy Atom Count:10
Complexity:124

Purity/Quality:

97% ^*data from raw suppliers

5-Chloro-2,4-difluoro-6-methylpyrimidine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi,Xn
Statements: 36/37/38-41-37/38-22
Safety Statements: 26-36/37/39-39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(=NC(=N1)F)F)Cl
Uses 5-Chloro-2,4-difluoro-6-methylpyrimidine (cas# 72630-78-5) is a compound useful in organic synthesis.

Technology Process of 5-Chloro-2,4-difluoro-6-methylpyrimidine

There total 2 articles about 5-Chloro-2,4-difluoro-6-methylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 6554-69-4
6-Methyl-2,4,5-trichloropyrimidine

: 72630-78-5
2,4-difluoro-5-chloro-6-methyl pyrimidine

Guidance literature:: With hydrogen fluoride; at 100 - 140 ℃; for 6h; under 15001.2 Torr;
DOI:10.1016/S0022-1139(00)81461-X

Reference yield: 40.0%

: 6554-69-4
6-Methyl-2,4,5-trichloropyrimidine

: 72630-78-5
2,4-difluoro-5-chloro-6-methyl pyrimidine

: 4-fluoro-2,5-dichloro-6-methylpyrimidine

Guidance literature:: With potassium fluoride; 18-crown-6 ether; In nitrobenzene; at 208 ℃; for 7h; Kinetics; Mechanism; Thermodynamic data; var. solvent, catalyst, fluorinating agent; ΔH(excit.), ΔS(excit.), ΔEa(excit.);
DOI:10.1016/S0022-1139(00)85019-8