4,4'-dimethyl-2,3,5,6-tetrafluorobibenzyl

Base Information

• Chemical Name: 4,4'-dimethyl-2,3,5,6-tetrafluorobibenzyl
• CAS No.: 106358-39-8
• Molecular Formula: C₁₆H₁₄F₄
• Molecular Weight: 282.281
• Mol file: 106358-39-8.mol

Synonyms:4,4'-dimethyl-2,3,5,6-tetrafluorobibenzyl

Chemical Property of 4,4'-dimethyl-2,3,5,6-tetrafluorobibenzyl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,4'-dimethyl-2,3,5,6-tetrafluorobibenzyl

There total 12 articles about 4,4'-dimethyl-2,3,5,6-tetrafluorobibenzyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methyllithium (917-54-4) + 2,3,4,5,6-pentafluoro-4'-methylbibenzyl (106358-38-7) → 4,4'-dimethyl-2,3,5,6-tetrafluorobibenzyl (106358-39-8)

Guidance literature:

In diethyl ether; for 3h; Heating;

DOI:10.1021/jo00380a006

Reference yield:

(2,3,4,5,6-pentafluorobenzyl)triphenylphosphonium bromide (13509-91-6) → 4,4'-dimethyl-2,3,5,6-tetrafluorobibenzyl (106358-39-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) CH₃Li / 1.) ether, RT, 3 h, 2.) ether

2: 98 percent / H₂ / 5percent Pd/C / methanol / 11 h / 2068.6 Torr

3: 90 percent / diethyl ether / 3 h / Heating

With methyllithium; hydrogen; palladium on activated charcoal; In methanol; diethyl ether;

DOI:10.1021/jo00380a006

Reference yield:

(E)-1,2,3,4,5-pentafluoro-6-styrylbenzene (80365-31-7,19292-25-2) → 4,4'-dimethyl-2,3,5,6-tetrafluorobibenzyl (106358-39-8)

Guidance literature:

Multi-step reaction with 7 steps

1: H₂ / Pd-C

2: LiAlH₄ / 1,2-dimethoxy-ethane

3: (i) nBuLi, (ii) /BRN= 636496/

4: LiAlH₄

5: PBr₃

7: Na / xylene

With lithium aluminium tetrahydride; hydrogen; sodium; phosphorus tribromide; palladium on activated charcoal; In 1,2-dimethoxyethane; xylene;

DOI:10.1021/ja01035a054

upstream raw materials:

methyllithium

2,3,4,5,6-pentafluoro-4'-methylbibenzyl

1-bromomethyl-2,3,5,6-tetrafluoro-4-methylbenzene

4-Methylbenzyl bromide

Downstream raw materials:

3'-acetyl-4,4'-dimethyl-2,3,5,6-tetrafluorobibenzyl