Technology Process of (E)-4,4-dimethyl-1-phenyldeca-1,9-dien-5-one
There total 6 articles about (E)-4,4-dimethyl-1-phenyldeca-1,9-dien-5-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Jones reagent;
In
diethyl ether;
at 0 - 20 ℃;
for 1h;
DOI:10.1021/ol502258n
- Guidance literature:
-
Multi-step reaction with 2 steps
1: tetrahydrofuran / 4 h / 0 - 20 °C
2: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / 2 h / -78 - 20 °C
With
oxalyl dichloride; dimethyl sulfoxide; triethylamine;
In
tetrahydrofuran; dichloromethane;
2: |Swern Oxidation;
DOI:10.1002/anie.201308617
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 1 h / -50 - -5 °C / Inert atmosphere
1.2: 10 h / -50 - 20 °C / Inert atmosphere
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C
3.1: pyridinium chlorochromate; silica gel / dichloromethane / 2 h / 20 °C
4.1: magnesium; iodine / tetrahydrofuran / 20 °C / Inert atmosphere
4.2: Inert atmosphere
5.1: Jones reagent / diethyl ether / 1 h / 0 - 20 °C
With
lithium aluminium tetrahydride; Jones reagent; n-butyllithium; iodine; silica gel; magnesium; diisopropylamine; pyridinium chlorochromate;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.1021/ol502258n
