Piperazine-1-carboxamide Hydrochloride

Base Information

• Chemical Name: Piperazine-1-carboxamide Hydrochloride
• CAS No.: 474711-89-2
• Molecular Formula: C5H12ClN3O
• Molecular Weight: 165.623
• Hs Code.: 2933599090
• European Community (EC) Number: 673-873-4
• DSSTox Substance ID: DTXSID00377840
• Mol file: 474711-89-2.mol

Synonyms:474711-89-2;Piperazine-1-carboxamide Hydrochloride;Piperazine-1-carboxylic acid amide hydrochloride;piperazine-1-carboxylic acid amide hcl;piperazine-1-carboxamide;hydrochloride;MFCD06408948;1-piperazinecarboxamide hydrochloride;1-Piperazinecarboxamide, monohydrochloride;PIPERAZINE-1-CARBOXYLICACIDAMIDEHCL;SCHEMBL956960;DTXSID00377840;piperazinecarboxamide hydrochloride;UVYKKFKLOUEFAR-UHFFFAOYSA-N;ZTA71189;PIPERAZINE-1-CARBOXAMIDE HCL;AKOS015849177;DS-9855;BP-10505;Piperazine-1-carboxylic acid amide x HCl;1-Piperazinecarboxamide,hydrochloride(1:1);CS-0149933;FT-0678368;EN300-35113;C15836;A827241;Z1473962055;piperazine-1-carboxylic acid amide hydrochloride, AldrichCPR

Chemical Property of Piperazine-1-carboxamide Hydrochloride

Chemical Property:

• Vapor Pressure: 0.0172mmHg at 25°C
• Melting Point: 221-224 °C
• Refractive Index: 1.509
• Boiling Point: 254.5 °C at 760 mmHg
• Flash Point: 107.7 °C
• PSA: 58.36000
• Density: 1.153g/cm3
• LogP: 0.73930
• Storage Temp.: Inert atmosphere,Room Temperature
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 165.0668897
• Heavy Atom Count: 10
• Complexity: 109

Purity/Quality:

97% ^*data from raw suppliers

Piperazine-1-carboxamideHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCN1)C(=O)N.Cl
• Uses: Piperazine-1-carboxamide Hydrochloride is used in preparation of heteroaromatic derivatives as PDE4 inhibitors.

Technology Process of Piperazine-1-carboxamide Hydrochloride

There total 2 articles about Piperazine-1-carboxamide Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 4-carbamoylpiperazine-1-carboxylate (883554-88-9) → piperazine-1-carboxamide hydrochloride (474711-89-2)

Guidance literature:

With hydrogenchloride; In dichloromethane; ethyl acetate; at 20 ℃; for 0.5h; Inert atmosphere;

Reference yield:

→ piperazine-1-carboxamide hydrochloride (474711-89-2)

Guidance literature:

Reference yield: 70.0%

piperazine-1-carboxamide hydrochloride (474711-89-2) + (S)-5-(1-((tert-butoxycarbonyl)amino)ethyl)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-1,3-oxazole-4-carboxylic acid → (S)-(1-(4-(4-carbamoylpiperazine-1-carbonyl)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)oxazol-5-yl)ethyl)carbamic acid t-butyl ester

Guidance literature:

With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 5h; Inert atmosphere;

upstream raw materials:

tert-butyl 4-carbamoylpiperazine-1-carboxylate

Downstream raw materials:

4-{4-[(3S)-2,3-dihydro[1,4]dioxino[2,3-b]pyridin-3-yl]benzyl}piperazine-1-carboxamide