4-(4-Bromo-2-fluoro-benzoyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid ethyl ester

Base Information

• Chemical Name: 4-(4-Bromo-2-fluoro-benzoyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid ethyl ester
• CAS No.: 151982-61-5
• Molecular Formula: C₁₆H₁₅BrFNO₃
• Molecular Weight: 368.202

Synonyms:4-(4-Bromo-2-fluoro-benzoyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid ethyl ester

Chemical Property of 4-(4-Bromo-2-fluoro-benzoyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid ethyl ester

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Technology Process of 4-(4-Bromo-2-fluoro-benzoyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid ethyl ester

There total 2 articles about 4-(4-Bromo-2-fluoro-benzoyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3,5-dimethyl-2-ethoxycarbonyl-1H-pyrrole (2199-44-2) + 4-bromo-2-fluorobenzoyl chloride (151982-51-3) → 4-(4-Bromo-2-fluoro-benzoyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid ethyl ester (151982-61-5)

Guidance literature:

With aluminium trichloride; In dichloromethane; for 2h; Heating;

DOI:10.1016/0223-5234(93)90016-8

Reference yield:

2-fluoro-4-bromobenzoic acid (112704-79-7) → 4-(4-Bromo-2-fluoro-benzoyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid ethyl ester (151982-61-5)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂

2: 95 percent / AlCl₃ / CH₂Cl₂ / 2 h / Heating

With aluminium trichloride; thionyl chloride; In dichloromethane;

DOI:10.1016/0223-5234(93)90016-8

Reference yield: 63.0%

4-(4-Bromo-2-fluoro-benzoyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid ethyl ester (151982-61-5) → 4-(4-Bromo-2-fluoro-benzyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid ethyl ester (151982-70-6)

Guidance literature:

With triethylsilane; In trifluoroacetic acid; for 16h; Ambient temperature;

DOI:10.1016/0223-5234(93)90016-8

upstream raw materials:

3,5-dimethyl-2-ethoxycarbonyl-1H-pyrrole

4-bromo-2-fluorobenzoyl chloride

2-fluoro-4-bromobenzoic acid

Downstream raw materials:

4-(4-Bromo-2-fluoro-benzyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid ethyl ester

4-(4-Bromo-2-fluoro-benzyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid

{[4-(4-Bromo-2-fluoro-benzyl)-3,5-dimethyl-1H-pyrrole-2-carbonyl]-amino}-acetic acid ethyl ester

[6-(4-Bromo-2-fluoro-benzyl)-5,7-dimethyl-1,3-dioxo-1H-pyrrolo[1,2-c]imidazol-2-yl]-acetic acid ethyl ester

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