[(4-chloro-benzyl)-(3-trifluoromethyl-benzenesulfonyl)-amino]-acetic acid tert-butyl ester

Base Information

• Chemical Name: [(4-chloro-benzyl)-(3-trifluoromethyl-benzenesulfonyl)-amino]-acetic acid tert-butyl ester
• CAS No.: 245364-72-1
• Molecular Formula: C₂₀H₂₁ClF₃NO₄S
• Molecular Weight: 463.905

Synonyms:[(4-chloro-benzyl)-(3-trifluoromethyl-benzenesulfonyl)-amino]-acetic acid tert-butyl ester

Chemical Property of [(4-chloro-benzyl)-(3-trifluoromethyl-benzenesulfonyl)-amino]-acetic acid tert-butyl ester

Chemical Property:

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Technology Process of [(4-chloro-benzyl)-(3-trifluoromethyl-benzenesulfonyl)-amino]-acetic acid tert-butyl ester

There total 3 articles about [(4-chloro-benzyl)-(3-trifluoromethyl-benzenesulfonyl)-amino]-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-chlorobenzyl bromide (622-95-7) + (3-trifluoromethyl-benzenesulfonylamino)-acetic acid tert-butyl ester (245364-63-0) → [(4-chloro-benzyl)-(3-trifluoromethyl-benzenesulfonyl)-amino]-acetic acid tert-butyl ester (245364-72-1)

Guidance literature:

With polystyrene-bound 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; In dichloromethane;

DOI:10.1016/S0960-894X(99)00311-X

Reference yield:

3-(Trifluoromethyl)benzenesulfonyl chloride (777-44-6) → [(4-chloro-benzyl)-(3-trifluoromethyl-benzenesulfonyl)-amino]-acetic acid tert-butyl ester (245364-72-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / pyridine

2: 100 percent / polymer-supported phosphazene - BEMP on polystyrene / CH₂Cl₂

With pyridine; polystyrene-bound 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; In dichloromethane;

DOI:10.1016/S0960-894X(99)00311-X

Reference yield:

glycine tert-butyl ester hydrochloride (27532-96-3) → [(4-chloro-benzyl)-(3-trifluoromethyl-benzenesulfonyl)-amino]-acetic acid tert-butyl ester (245364-72-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / pyridine

2: 100 percent / polymer-supported phosphazene - BEMP on polystyrene / CH₂Cl₂

With pyridine; polystyrene-bound 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; In dichloromethane;

DOI:10.1016/S0960-894X(99)00311-X

upstream raw materials:

4-chlorobenzyl bromide

(3-trifluoromethyl-benzenesulfonylamino)-acetic acid tert-butyl ester

3-(Trifluoromethyl)benzenesulfonyl chloride

glycine tert-butyl ester hydrochloride

Downstream raw materials:

N-benzyloxy-2-[(4-chloro-benzyl)-(3-trifluoromethyl-benzenesulfonyl)-amino]-acetamide

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