Technology Process of 1,1'-Bis(benzyloxy)-4,4'-diphenyl-5,5'-bipyrazolyl
There total 5 articles about 1,1'-Bis(benzyloxy)-4,4'-diphenyl-5,5'-bipyrazolyl which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
bis-triphenylphosphine-palladium(II) chloride;
In
1,2-dimethoxyethane;
at 70 ℃;
for 24h;
DOI:10.1039/b010126p
- Guidance literature:
-
1,1'-Bis(benzyloxy)-4,4'-diiodo-5,5'-bipyrazolyl;
With
phenylmagnesium chloride;
In
tetrahydrofuran;
at 20 ℃;
for 5.5h;
iodobenzene;
With
zinc(II) chloride;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; N,N-dimethyl-formamide;
at 70 ℃;
for 17h;
Further stages.;
DOI:10.1039/b010126p
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: n-BuLi / tetrahydrofuran; hexane / 0.17 h / -78 °C
1.2: ZnCl2 / tetrahydrofuran; hexane / -78 - 20 °C
1.3: 88 percent / Pd(PPh3)4 / tetrahydrofuran; hexane; dimethylformamide / 19 h / 60 °C
2.1: K2CO3; ICl / CHCl3 / 96 h / 20 °C
3.1: PhMgCl / tetrahydrofuran / 5.5 h / 20 °C
3.2: 70 percent / ZnCl2 / Pd(PPh3)4 / tetrahydrofuran; dimethylformamide / 17 h / 70 °C
With
n-butyllithium; phenylmagnesium chloride; Iodine monochloride; potassium carbonate;
In
tetrahydrofuran; hexane; chloroform;
1.3: Negishi cross-coupling / 3.2: Negishi cross-coupling;
DOI:10.1039/b010126p
