1,2-DIMETHYL-PIPERAZINE

Base Information

• Chemical Name: 1,2-DIMETHYL-PIPERAZINE
• CAS No.: 25057-77-6
• Molecular Formula: C6H14 N2
• Molecular Weight: 114.191
• Hs Code.: 29335990
• Mol file: 25057-77-6.mol

Synonyms:1,2-Dimethylpiperazine

Chemical Property of 1,2-DIMETHYL-PIPERAZINE

Chemical Property:

• Boiling Point: 147°Cat760mmHg
• PKA: 9.31±0.40(Predicted)
• Flash Point: 44.9°C
• PSA: 15.27000
• Density: 0.855g/cm³
• LogP: 0.17660
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

1,2-Dimethylpiperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2-DIMETHYL-PIPERAZINE

There total 12 articles about 1,2-DIMETHYL-PIPERAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

3,4-dimethyl-piperazine-1-carboxylic acid ethyl ester (114649-94-4) → 1,2-dimethylpiperazine (25057-77-6)

Guidance literature:

With hydrogenchloride; for 24h; Heating;

Reference yield:

tert-butyl 3,4-dimethylpiperazine-1-carboxylate (741287-32-1) → 1,2-dimethylpiperazine (25057-77-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

→ 1,2-dimethylpiperazine (25057-77-6)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/ja01123a008

upstream raw materials:

3,4-dimethyl-piperazine-1-carboxylic acid ethyl ester

3-methylpiperazin-2-one

3-methylpiperazine-1-carboxylic acid ethyl ester

4-benzyl-3-methyl-piperazine-1-carboxylic acid ethyl ester

Refernces

Synthesis and biological evaluation of novel delta (δ) opioid receptor ligands with diazatricyclodecane skeletons

10.1016/j.ejmech.2013.09.014

The study investigates the creation and pharmacological assessment of new d opioid receptor ligands. These ligands are synthesized by replacing the dimethylpiperazine core motif of the selective d opioid agonist SNC-80 with diazatricyclodecane ring systems. The synthesized compounds exhibit subnanomolar to low nanomolar binding affinities for the d opioid receptor and varying selectivity over m and k receptors. Key chemicals involved include the reference compound SNC-80, and the novel compounds such as 1Aa, 1Ba, 2Aa, and 2Ba, which are derivatives of 9,10-diazatricyclo[4.2.1.12,5]decane and 2,7-diazatricyclo[4.4.0.03,8]decane. These compounds are evaluated for their binding affinities, intrinsic activity using isolated mouse vas deferens assays, and antinociceptive activity in a tail flick test. The study identifies 1Aa as a promising candidate with higher d affinity and selectivity compared to SNC-80, demonstrating significant d agonist activity and antinociceptive effects. Future work will focus on separating and characterizing the enantiomers of these compounds to further explore their potential as therapeutic agents for d opioid receptor mediated pathologies.