1,2-DIMETHYL-PIPERAZINE

Base Information

• Chemical Name: 1,2-DIMETHYL-PIPERAZINE
• CAS No.: 25057-77-6
• Molecular Formula: C6H14 N2
• Molecular Weight: 114.191
• Hs Code.: 29335990
• Mol file: 25057-77-6.mol

Synonyms:1,2-Dimethylpiperazine

Chemical Property of 1,2-DIMETHYL-PIPERAZINE

Chemical Property:

• Boiling Point: 147°Cat760mmHg
• PKA: 9.31±0.40(Predicted)
• Flash Point: 44.9°C
• PSA: 15.27000
• Density: 0.855g/cm³
• LogP: 0.17660
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%min ^*data from raw suppliers

1,2-Dimethylpiperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2-DIMETHYL-PIPERAZINE

There total 12 articles about 1,2-DIMETHYL-PIPERAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

3,4-dimethyl-piperazine-1-carboxylic acid ethyl ester (114649-94-4) → 1,2-dimethylpiperazine (25057-77-6)

Guidance literature:

With hydrogenchloride; for 24h; Heating;

Reference yield:

tert-butyl 3,4-dimethylpiperazine-1-carboxylate (741287-32-1) → 1,2-dimethylpiperazine (25057-77-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

→ 1,2-dimethylpiperazine (25057-77-6)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/ja01123a008

upstream raw materials:

3,4-dimethyl-piperazine-1-carboxylic acid ethyl ester

3-methylpiperazin-2-one

3-methylpiperazine-1-carboxylic acid ethyl ester

4-benzyl-3-methyl-piperazine-1-carboxylic acid ethyl ester

Downstream raw materials:

8-(4-((3,4-dimethylpiperazin-1-yl)methyl)phenyl)-9-(4-fluorophenyl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

Refernces

• 1、 -. "METHODS OF USING DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY (ADP-RIBOSE)POLYMERASE (PARP)". Page/Page column 180-181. . Retrieved 2011/11/01.
• 2、 -. "Process for preparing cis-2,6-dimethylpiperazine". . . Retrieved 2008/06/13.