(R)-2-amino-3-(3-ethoxycarbonyl-6-morpholino-4-phenylpyridin-2-ylthio)propionic acid

Base Information

Chemical Name:(R)-2-amino-3-(3-ethoxycarbonyl-6-morpholino-4-phenylpyridin-2-ylthio)propionic acid
CAS No.:1333235-44-1
Molecular Formula:C₂₁H₂₅N₃O₅S
Molecular Weight:431.513
Hs Code.:

Synonyms:(R)-2-amino-3-(3-ethoxycarbonyl-6-morpholino-4-phenylpyridin-2-ylthio)propionic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-amino-3-(3-ethoxycarbonyl-6-morpholino-4-phenylpyridin-2-ylthio)propionic acid

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Technology Process of (R)-2-amino-3-(3-ethoxycarbonyl-6-morpholino-4-phenylpyridin-2-ylthio)propionic acid

There total 2 articles about (R)-2-amino-3-(3-ethoxycarbonyl-6-morpholino-4-phenylpyridin-2-ylthio)propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: Ni(II)-(S)-BPB-D-Ala

: 50706-80-4
2-mercapto-6-morpholino-4-phenyl-nicotinic acid ethyl ester

: 1333235-44-1
(R)-2-amino-3-(3-ethoxycarbonyl-6-morpholino-4-phenylpyridin-2-ylthio)propionic acid

: (S)-2-amino-3-(3-ethoxycarbonyl-6-morpholino-4-phenylpyridin-2-ylthio)propionic acid

: 96293-17-3,105024-93-9,105112-33-2
(S)-N-(2-benzoylphenyl)-1-benzylpyrrolidine-2-carboxamide

Guidance literature:: Ni(II)-(S)-BPB-D-Ala; 2-mercapto-6-morpholino-4-phenyl-nicotinic acid ethyl ester; With potassium carbonate; In acetonitrile; at 25 ℃; for 0.166667h; Inert atmosphere;

With water; optical yield given as %ee; diastereoselective reaction; Acidic conditions;
DOI:10.1016/j.tetasy.2012.05.022