5-Methoxy-2--acetophenon

Base Information

• Chemical Name: 5-Methoxy-2--acetophenon
• CAS No.: 93044-95-2
• Molecular Formula: C₁₄H₁₂O₄S
• Molecular Weight: 276.313
• Mol file: 93044-95-2.mol

Synonyms:5-Methoxy-2--acetophenon

Chemical Property of 5-Methoxy-2--acetophenon

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Methoxy-2--acetophenon

There total 1 articles about 5-Methoxy-2--acetophenon which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Thiophenecarbonyl chloride (5271-67-0) + 1-(2-hydroxy-5-methoxyphenyl)ethan-1-one (705-15-7) → 5-Methoxy-2--acetophenon (93044-95-2)

Guidance literature:

With pyridine; at 25 ℃;

DOI:10.1016/j.bcp.2014.02.013

Reference yield:

5-Methoxy-2--acetophenon (93044-95-2) → 1-(2-hydroxy-5-methoxyphenyl)-3-(thiophen-2-yl)propane-1,3-dione (92254-78-9)

Guidance literature:

With pyridine; potassium hydroxide; at 60 ℃;

DOI:10.1016/j.bcp.2014.02.013

Reference yield:

5-Methoxy-2--acetophenon (93044-95-2) → 3-(4-hydroxybenzyl)-7-methoxy-1-(thiophen-2-yl)chromeno[2,3-c]pyrrol-9(2H)-one (1433961-76-2)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine; potassium hydroxide / 60 °C

2: dicyclohexyl-carbodiimide; dmap; pyridine / 20 - 50 °C

3: trifluoroacetic acid / dichloromethane / 20 °C

With pyridine; dmap; dicyclohexyl-carbodiimide; trifluoroacetic acid; potassium hydroxide; In dichloromethane;

DOI:10.1016/j.bcp.2014.02.013

upstream raw materials:

2-Thiophenecarbonyl chloride

1-(2-hydroxy-5-methoxyphenyl)ethan-1-one

Downstream raw materials:

3-(4-(tert-butoxy)benzyl)-7-methoxy-1-(thiophen-2-yl)chromeno[2,3-c]pyrrol-9(2H)-one

3-(4-hydroxybenzyl)-7-methoxy-1-(thiophen-2-yl)chromeno[2,3-c]pyrrol-9(2H)-one

1-(2-hydroxy-5-methoxyphenyl)-3-(thiophen-2-yl)propane-1,3-dione