(S)-1-(6-(4-(2,6-difluorophenyl)pyrimidin-2-yl)quinolin-4-yl)piperidin-3-amine

Base Information

Chemical Name:(S)-1-(6-(4-(2,6-difluorophenyl)pyrimidin-2-yl)quinolin-4-yl)piperidin-3-amine
CAS No.:1214241-72-1
Molecular Formula:C₂₄H₂₁F₂N₅
Molecular Weight:417.461
Hs Code.:

Synonyms:(S)-1-(6-(4-(2,6-difluorophenyl)pyrimidin-2-yl)quinolin-4-yl)piperidin-3-amine

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Chemical Property of (S)-1-(6-(4-(2,6-difluorophenyl)pyrimidin-2-yl)quinolin-4-yl)piperidin-3-amine

Chemical Property:

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Technology Process of (S)-1-(6-(4-(2,6-difluorophenyl)pyrimidin-2-yl)quinolin-4-yl)piperidin-3-amine

There total 8 articles about (S)-1-(6-(4-(2,6-difluorophenyl)pyrimidin-2-yl)quinolin-4-yl)piperidin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₂₉F₂N₅O₂

: 1214241-72-1
(S)-1-(6-(4-(2,6-difluorophenyl)pyrimidin-2-yl)quinolin-4-yl)piperidin-3-amine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 1h;

Reference yield:

: 65340-70-7
6-bromo-4-chloroquinoline

: 1214241-72-1
(S)-1-(6-(4-(2,6-difluorophenyl)pyrimidin-2-yl)quinolin-4-yl)piperidin-3-amine

Guidance literature:: Multi-step reaction with 7 steps

1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 48 h / 140 °C

2: potassium acetate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 0.33 h / 135 °C / Microwave irradiation

3: water; sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 0.33 h / 125 °C / Microwave irradiation

4: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 12 h

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 105 °C / Microwave irradiation

6: water; sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 0.25 h / 120 °C / Microwave irradiation

7: trifluoroacetic acid / dichloromethane / 1 h

With water; hydrogen; potassium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; tricyclohexylphosphine; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; ethanol; dichloromethane; ethyl acetate;

Reference yield:

: 216854-23-8,172603-05-3
tert-butyl (S)-piperidin-3-yl-carbamate

: 1214241-72-1
(S)-1-(6-(4-(2,6-difluorophenyl)pyrimidin-2-yl)quinolin-4-yl)piperidin-3-amine

Guidance literature:: Multi-step reaction with 7 steps

1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 48 h / 140 °C

2: potassium acetate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 0.33 h / 135 °C / Microwave irradiation

3: water; sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 0.33 h / 125 °C / Microwave irradiation

4: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 12 h

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 105 °C / Microwave irradiation

6: water; sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 0.25 h / 120 °C / Microwave irradiation

7: trifluoroacetic acid / dichloromethane / 1 h

With water; hydrogen; potassium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; tricyclohexylphosphine; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; ethanol; dichloromethane; ethyl acetate;