[(R)-1-(2,4-Dimethoxy-benzyl)-3-isobutyl-2-oxo-azetidin-3-yl]-carbamic acid benzyl ester

Base Information

Chemical Name:[(R)-1-(2,4-Dimethoxy-benzyl)-3-isobutyl-2-oxo-azetidin-3-yl]-carbamic acid benzyl ester
CAS No.:928824-31-1
Molecular Formula:C₂₄H₃₀N₂O₅
Molecular Weight:426.513
Hs Code.:

Synonyms:[(R)-1-(2,4-Dimethoxy-benzyl)-3-isobutyl-2-oxo-azetidin-3-yl]-carbamic acid benzyl ester

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Chemical Property of [(R)-1-(2,4-Dimethoxy-benzyl)-3-isobutyl-2-oxo-azetidin-3-yl]-carbamic acid benzyl ester

Chemical Property:

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Technology Process of [(R)-1-(2,4-Dimethoxy-benzyl)-3-isobutyl-2-oxo-azetidin-3-yl]-carbamic acid benzyl ester

There total 1 articles about [(R)-1-(2,4-Dimethoxy-benzyl)-3-isobutyl-2-oxo-azetidin-3-yl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 51021-87-5
N-benzyloxycarbonyl-L-leucine methyl ester

: 94459-09-3
<(2,4-dimethoxybenzyl)amino>acetonitrile

: 928824-31-1
[(R)-1-(2,4-Dimethoxy-benzyl)-3-isobutyl-2-oxo-azetidin-3-yl]-carbamic acid benzyl ester

: [(S)-1-(2,4-Dimethoxy-benzyl)-3-isobutyl-2-oxo-azetidin-3-yl]-carbamic acid benzyl ester

Guidance literature:: N-benzyloxycarbonyl-L-leucine methyl ester; With lithium hexamethyldisilazane; In acetonitrile; at -70 ℃;

<(2,4-dimethoxybenzyl)amino>acetonitrile; In acetonitrile; at -70 - 20 ℃;
DOI:10.1016/j.bmcl.2006.10.047

Reference yield:

: 928824-31-1
[(R)-1-(2,4-Dimethoxy-benzyl)-3-isobutyl-2-oxo-azetidin-3-yl]-carbamic acid benzyl ester

: (R)-3-Amino-1-(2,4-dimethoxy-benzyl)-3-isobutyl-azetidin-2-one

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃;
DOI:10.1016/j.bmcl.2006.10.047

Reference yield:

: 928824-31-1
[(R)-1-(2,4-Dimethoxy-benzyl)-3-isobutyl-2-oxo-azetidin-3-yl]-carbamic acid benzyl ester

: 928824-18-4
[(S)-1-((R)-3-Isobutyl-2-oxo-azetidin-3-ylcarbamoyl)-2-methyl-propyl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C / methanol / 20 °C

2: TPTU; DIEA / dimethylformamide / 20 °C

3: K₂S₂O₈; Na₂HPO₄ / acetonitrile; H₂O

With disodium hydrogenphosphate; dipotassium peroxodisulfate; hydrogen; O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2006.10.047