dimethyl (S)-2-[1-(2,4-dimethoxyphenyl)-2-nitroethyl]-2-fluoromalonate

Base Information

• Chemical Name: dimethyl (S)-2-[1-(2,4-dimethoxyphenyl)-2-nitroethyl]-2-fluoromalonate
• CAS No.: 1170727-42-0
• Molecular Formula: C₁₅H₁₈FNO₈
• Molecular Weight: 359.308
• Mol file: 1170727-42-0.mol

Synonyms:dimethyl (S)-2-[1-(2,4-dimethoxyphenyl)-2-nitroethyl]-2-fluoromalonate

Chemical Property of dimethyl (S)-2-[1-(2,4-dimethoxyphenyl)-2-nitroethyl]-2-fluoromalonate

Chemical Property:

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Technology Process of dimethyl (S)-2-[1-(2,4-dimethoxyphenyl)-2-nitroethyl]-2-fluoromalonate

There total 1 articles about dimethyl (S)-2-[1-(2,4-dimethoxyphenyl)-2-nitroethyl]-2-fluoromalonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

dimethyl 2-fluoromalonate (344-14-9) + (E)-2,4-dimethoxy-β-nitrostyrene (37630-19-6) → dimethyl (S)-2-[1-(2,4-dimethoxyphenyl)-2-nitroethyl]-2-fluoromalonate (1170727-42-0)

Guidance literature:

With PHN-DHQ-OH; In chloroform; at 20 ℃; for 168h; optical yield given as %ee; enantioselective reaction;

DOI:10.1055/s-0028-1088124

upstream raw materials:

dimethyl 2-fluoromalonate

(E)-2,4-dimethoxy-β-nitrostyrene