(2S,4aR,5S,8aR)-N-benzyl-5-methyl-2-propyldecahydroquinoline

Base Information

Chemical Name:(2S,4aR,5S,8aR)-N-benzyl-5-methyl-2-propyldecahydroquinoline
CAS No.:850538-43-1
Molecular Formula:C₂₀H₃₁N
Molecular Weight:285.473
Hs Code.:

Synonyms:(2S,4aR,5S,8aR)-N-benzyl-5-methyl-2-propyldecahydroquinoline

Suppliers and Price of (2S,4aR,5S,8aR)-N-benzyl-5-methyl-2-propyldecahydroquinoline

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Chemical Property of (2S,4aR,5S,8aR)-N-benzyl-5-methyl-2-propyldecahydroquinoline

Chemical Property:

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Technology Process of (2S,4aR,5S,8aR)-N-benzyl-5-methyl-2-propyldecahydroquinoline

There total 9 articles about (2S,4aR,5S,8aR)-N-benzyl-5-methyl-2-propyldecahydroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 850538-40-8
(S)-2-nitro-N-(1-propylbut-3-enyl)benzenesulfonamide

: 850538-43-1
(2S,4aR,5S,8aR)-N-benzyl-5-methyl-2-propyldecahydroquinoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: 83 percent / PPh₃; DIAD / tetrahydrofuran / 72 h / 20 °C

2.1: 96 percent / ethylene / Grubbs I catalyst / CH₂Cl₂ / 24 h / 50 °C

3.1: K₂CO₃; thiophenol / dimethylformamide / 2 h / 80 °C

3.2: 95 percent / TBAI / dimethylformamide / 1 h / 80 °C

4.1: 74 percent / n-BuLi / Cp₂ZrCl₂ / tetrahydrofuran / -78 - 20 °C

With n-butyllithium; ethene; di-isopropyl azodicarboxylate; potassium carbonate; thiophenol; triphenylphosphine; Grubbs catalyst first generation; zirconocene dichloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1.1: Mitsunobu reaction / 4.1: Negishi coupling;
DOI:10.1021/ol0474610

Reference yield:

: 850538-39-5
N-(R)-cyclohex-2-enyl-2-nitro-N-((S)-1-propylbut-3-enyl)benzenesulfonamide

: 850538-43-1
(2S,4aR,5S,8aR)-N-benzyl-5-methyl-2-propyldecahydroquinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: 96 percent / ethylene / Grubbs I catalyst / CH₂Cl₂ / 24 h / 50 °C

2.1: K₂CO₃; thiophenol / dimethylformamide / 2 h / 80 °C

2.2: 95 percent / TBAI / dimethylformamide / 1 h / 80 °C

3.1: 74 percent / n-BuLi / Cp₂ZrCl₂ / tetrahydrofuran / -78 - 20 °C

With n-butyllithium; ethene; potassium carbonate; thiophenol; Grubbs catalyst first generation; zirconocene dichloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 3.1: Negishi coupling;
DOI:10.1021/ol0474610

Reference yield:

: 850538-37-3
(2S,6R)-N-(2-nitrobenzenesulfonyl)-6-pent-4-enyl-2-propyl-1,2,3,6-tetrahydropyridine

: 850538-43-1
(2S,4aR,5S,8aR)-N-benzyl-5-methyl-2-propyldecahydroquinoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: K₂CO₃; thiophenol / dimethylformamide / 2 h / 80 °C

1.2: 95 percent / TBAI / dimethylformamide / 1 h / 80 °C

2.1: 74 percent / n-BuLi / Cp₂ZrCl₂ / tetrahydrofuran / -78 - 20 °C

With n-butyllithium; potassium carbonate; thiophenol; zirconocene dichloride; In tetrahydrofuran; N,N-dimethyl-formamide; 2.1: Negishi coupling;
DOI:10.1021/ol0474610