Benzeneacetamide, 4-(acetylamino)-N-[4-amino-1,2,3,6-tetrahydro-2,6-dioxo-1-(phenylmethyl)-5-pyrimidinyl]-

Base Information

• Chemical Name: Benzeneacetamide, 4-(acetylamino)-N-[4-amino-1,2,3,6-tetrahydro-2,6-dioxo-1-(phenylmethyl)-5-pyrimidinyl]-
• CAS No.: 637334-91-9
• Molecular Formula: C₂₁H₂₁N₅O₄
• Molecular Weight: 407.429
• Mol file: 637334-91-9.mol

Synonyms:2-(4-acetylamino-phenyl)-N-(6-amino-3-benzyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-acetamide

Chemical Property of Benzeneacetamide, 4-(acetylamino)-N-[4-amino-1,2,3,6-tetrahydro-2,6-dioxo-1-(phenylmethyl)-5-pyrimidinyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzeneacetamide, 4-(acetylamino)-N-[4-amino-1,2,3,6-tetrahydro-2,6-dioxo-1-(phenylmethyl)-5-pyrimidinyl]-

There total 2 articles about Benzeneacetamide, 4-(acetylamino)-N-[4-amino-1,2,3,6-tetrahydro-2,6-dioxo-1-(phenylmethyl)-5-pyrimidinyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-amino-3-benzyl-1-butyl-5-nitrosouracil (161419-60-9) → 2-(4-acetylamino-phenyl)-N-(6-amino-3-benzyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-acetamide (637334-91-9)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / platinum(IV) oxide / ethanol / 20 °C / 2585.81 Torr

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1H-imidazole; dmap / DMF (N,N-dimethyl-formamide) / 29 h / 20 °C

With hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1H-imidazole; dmap; platinum(IV) oxide; In DMF (N,N-dimethyl-formamide); ethanol;

Reference yield:

→ 2-(4-acetylamino-phenyl)-N-(6-amino-3-benzyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-acetamide (637334-91-9)

Guidance literature:

Reference yield:

2-(4-acetylamino-phenyl)-N-(6-amino-3-benzyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-acetamide (637334-91-9) + 3-(bromomethyl)furan (63184-61-2) → 2-(4-acetylamino-phenyl)-N-(6-amino-3-benzyl-1-furan-3-ylmethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-acetamide

Guidance literature:

With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 18h;

upstream raw materials:

6-amino-3-benzyl-1-butyl-5-nitrosouracil

Downstream raw materials:

N-[4-(1-benzyl-3-furan-3-ylmethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-ylmethyl)-phenyl]-acetamide